OBJECTIVE This study was conducted to resolve the striking controversy between our previous report that high-density lipoprotein (HDL) enhances activated protein C (APC)/protein S anticoagulant actions and a subsequent, contradicting report that HDL lacks this activity. APPROACH AND RESULTS When fresh HDL preparations from 2 laboratories were subjected to Superose 6 column chromatography, fra...

Anticoagulants are drugs used to inhibit the development and enlargement of a blood clot. Melon is known contain adenosime that function stop clotting cell chip. This study aims identify secondary metabolites contained in melon juice, fruit juice anticoagulant activity vivo melon, look for an effective dose as potential compared with aspirin. A total 15 male mice were divided into 5 groups, i.e...

abstract         background and objective: hirudin is an anticoagulant polypeptide secreted from the salivary glands of leeches. recombinant hirudin is a strong anticoagulant agent in arterial and venous thrombosis. the aim of this study was to evaluate the effect of inserting protein a signal peptide sequence of pezz18 plasmid on expression and secretion of the recombinant hirudin in e.coli.  ...

The aims of this study were to examine the bioactive component(s) responsible for the anticoagulant activity of M. malabathricum Linn. leaf hot water crude extract via bioassay-guided fractionation and to evaluate the effect of bioactive component(s) on the intrinsic blood coagulation pathway. The active anticoagulant fraction of F3 was subjected to a series of chromatographic separation and sp...