Cancer Therapy In article number 2300107, Moshi Song, Jun Wang, and colleagues used deep learning to identify functional peptides in the metagenome. cover image full of Chinese elements, center piece is a bamboo scroll, oldest form books that circulated represents coded information microbiome. From scroll book genomic/metagenomic information, important paragraphs or sentences (such as protein –...

The pharmacological sciences are taking advantage of recent discoveries that have defined the molecular pathways governing apoptosis. These signaling cascades are frequently inactivated or distorted by mutations in cancer cells. Peptides derived from critical interaction, phosphorylation, or cleavage sites are the preferred leads (starting points) for the development of new drugs. In this revie...

We previously reported that amphiphilic peptides containing one Lys and two His in the hydrophilic domain—KHHAAAAAA7 (KHHA7)—formed ternary complexes with intermediate metal ions a poorly water-soluble anticancer drug—paclitaxel (Ptx)—which improved water dispersibility of Ptx. In this study, effect KHHA7 on cell viability is evaluated vitro using HeLa cells. The reduced by approximately 60%, s...

Lactic Acid Bacteria (LAB) synthesize various metabolites during their growth phase and are Generally Recognized as­­ Safe (GRAS) Qualified Presumption of Safety (QPS). Ribosomally synthesized Antimicrobial Peptides (AMP) or Bacteriocins from the genera other prokaryotic cationic, heat-stable, amphiphilic membrane permeabilizing peptides built with an excess amount lysyl arginyl residues. compo...

Peptides are important structures that offer opportunities for therapeutic interventions in various diseases. Tyrosyl-Lysyl-Threonine is an peptide structure contains the antiviral, antioxidant and anticancer properties of amino acids its structure. Examination conformational structure, which has great importance on both ability molecule to fulfill biological functions electronic properties, mo...

objective(s):according to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. in the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. materials and methods:all synthesized derivatives were evaluated towards three hu...