PURPOSE To determine whether moxifloxacin can be used safely as an intraocular antibiotic, retinal safety of intravitreal moxifloxacin was studied with electroretinography (ERG) and histopathology in animal models. METHODS Moxifloxacin was injected into mouse eyes at intravitreal concentrations of 5 to 500 microg/mL and into rabbit eyes at 150 microg/mL. As the control, the vehicle was inject...

PURPOSE There is limited information on pediatric prescribing in Sierra Leone. This study evaluated prescribing patterns for under-five patients at Ola During Children's Hospital (ODCH) and assessed the extent of rational prescribing. METHODS A descriptive, cross-sectional, retrospective study of 294 prescriptions, selected by systematic random sampling was conducted at the outpatient departm...

OBJECTIVE In the post-sternotomy mediastinitis patients, Staphylococcus aureus is the pathogenic microorganism encountered most often. In our study, we aimed to determine the efficacy of antibiotic treatment with vancomycin and tigecycline, alone or in combination with hyperbaric oxygen treatment, on bacterial elimination in experimental S. aureus mediastinitis. METHODS Forty-nine adult femal...

BL-P1654 is a new ureido-penicillin which has significant activity against both pseudomonas and klebsiella. Its pharmacokinetics were evaluated in five studies in four healthy adult male volunteers after 1-g doses given as: 5- and 30-min intravenous infusions, a 30-min infusion 1 h after the oral administration of 1 g of probenecid, and an intramuscular injection. For comparison, volunteers als...

Nasal colonization plays an important role in the pathogenesis of Staphylococcus aureus infections. To identify characteristics associated with colonization, we studied a cross-section of a well-described cohort of HIV-seropositive and -seronegative active and former drug users considered at risk for staphylococcal infections. Sixty percent of the 217 subjects were Hispanic, 36% were women, 25%...

Ten years ago, Waksman and Lechevaller1 demonstrated the important antibiotic action of neomycin against the Koch bacillus. The effect of neomycin is even greater than that of streptomycin. Rake, Hobby and Donovick' have also demonstrated the antibiotic effect of neomycin in experimental tuberculosis. Because of its toxicity, Grumbach and Rist3 considered that parenteral neomycin injection was ...

Aim was evaluation of the effects of cosupplementation of, vitamins E and C, in preventing renal scarring in acute pyelonephritis. Animals and Treatments. Sixty rats were used, bacteria was injected through kidney. The rats were arranged randomly in 3 groups of 20 rats each. Rats in groups 1 and 2 were given once-daily intraperitoneal injections of gentamicin for ten consecutive days, beginning...

The use of radiolabeled antibiotics as diagnostic agents is an emerging area of medical research. Vibramycin is a semisynthetic antibiotic of the tetracycline family prescribed to treat a variety of infections. We present in this study a new technetium-99m labeled vibramycin radiopharmaceutical using SnCl2.2H2O as a reducing agent. The stability of 99mTc-vibramycin was evaluated in human serum ...

Gentamicin (GM) is a widely used antibiotic but shows renal toxicity. We produced a serum against GM (anti-GM) conjugated to bovine serum albumin with N-(gamma-maleimidobutyryloxy)succinimide. The antiserum was monospecific for GM and did not cross-react with the analog streptomycin, tobramycin, kanamycin, or amikacin. The antiserum also detected glutaraldehyde-fixed GM, and this enabled us to ...

PURPOSE Intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents including ranibizumab and aflibercept are used to treat patients with ocular disorders such as neovascular age-related macular degeneration (nAMD); however, the injections are associated with rare instances of severe ocular inflammation. This study compared severe ocular inflammation rates in patients treat...