Contemporary publications on possible pharmaceutical treatment of ototoxic effect aminoglycosides have been analyzed. In this respect, substances with the antioxidant seem to be most promising. Their use in therapeutic doses is not accompanied by adverse reactions, and they do interfere antibacterial anti-tuberculosis drugs. Currently, mechanisms otoprotective action various antioxidants are be...

Background Tuberculosis (TB) remains a significant global health problem, responsible for an estimated 1.7 million deaths per year worldwide [1]. Resistance to anti-tuberculosis drugs is an important threat to tuberculosis control. The risk of treatment failure and death with standard short-course chemotherapy is highest with resistance to both isoniazid and rifampicin (multidrug-resistant tube...

Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications are described for the treatment of TB. Regardless of availability of several drugs to treat TB, the causative agent, M. tuberculosis is nowadays getting resistant toward the conven...

Introduction: Tuberculosis is an infectious disease of the respiratory tract caused by Mycobacterium tuberculosis. During tuberculosis infection, pathogens modulate TLR-4 receptor flow signaling, suggesting possible involvement in regulation host immune response. This study aims to determine effect miana leaf extract on expression toll like 4 (TLR-4) mice at preventive and curative stages. Meth...

Tuberculosis is one of the oldest diseases that affects humans. The cause of this disease is Mycobacterium tuberculosis. This disease affects approximately 8.8 million people worldwide and led to over 3 million deaths in 1995. 95% of those affected and 98% of deaths occurred in developing countries. Hepatic reactions constitute a major proportion of drug reactions to antituberculosis drugs ...

Multidrug resistant tuberculosis (MDR-TB) has been an area of growing concern and is posing a threat to the control of tuberculosis (TB). The exact magnitude of problem of resistance to anti-tuberculosis drugs worldwide was not known till the 1994-97 global project on anti-tuberculosis drug resistance surveillance initiated by the World Health Organization (WHO) and International Union Against ...