The response of Mycobacterium tuberculosis to six anti-microbial agents was determined by microarray analysis in an attempt to define mechanisms of innate resistance in M. tuberculosis. The gene expression profiles of M. tuberculosis after treatment at the minimal inhibitory concentration (MIC) for 4 h with isoniazid, isoxyl, tetrahydrolipstatin, SRI#221, SR1#967 and SR1#9190 were compared to u...

background: human immunodeficiency virus (hiv) makes infected cases prone to opportunistic infections like tuberculosis (tb) due to impaired immunity of the body, especially multi drug resistant (mdr) ones which are a major concern. with hiv outbreak starting late in the 20th century, the international health community is observing a huge rise in the incidence of this complex disease. herein, w...

We evaluated the capacity of NK cells to influence expansion of CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) in response to microbial Ags, using Mycobacterium tuberculosis as a model. We previously found that Tregs expand when CD4(+) cells and monocytes are exposed to M. tuberculosis. Addition of NK cells that were activated by monokines (IL-12, IL-15, and IL-18) or by exposure to M. tuberc...

BACKGROUND Currently, hematopoietic stem cell transplantation is still an essential treatment approach for leukemia. However, patients with leukemia often have weakened immune function, especially more seriously compromised cellular immune response, and appear to be at greater risk for tuberculosis infection during the transplantation process. We aimed to investigate the efficacy and safety of ...

Tuberculosis (TB) is a disease which can affect various organs, including human's genital organs such as the endometrium. Tuberculosis endometritis can cause clinical symptoms of secondary amenorrhea and infertility. Infertility in genital TB caused by the involvement of the endometrium. The case presentation is 33-year-old woman from dr. Saiful Anwar Public Hospital to consult that she has not...

BACKGROUND Surveillance and effective management of drug resistance is important to sustaining tuberculosis (TB) control efforts. We aimed to determine resistance rates to first line anti tuberculosis drugs and to describe factors associated with the resistance to any of the first line anti tuberculosis drugs in Dar es Salaam Tanzania. MATERIALS Newly diagnosed, TB patients with neither histo...

the aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in iranian pulmonary tuberculosis patients. acetylating phenotypes was studied in 50 iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-isoniazid to isoniazid. the association between hepatotoxicity and the n-acetyltransferas...

BACKGROUND The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a global public health problem. Polyherbal medicines offer great hope for developing alternative drugs for the treatment of tuberculosis. OBJECTIVE To evaluate the anti-tubercular activity of polyherbal medicines used for the treatment of tuberculosis. METHODS The remedies were screened against Mycob...

any patient with bilateral lymphadenopathy especially in indian subcontinent is regarded as suffering from tuberculosis unless proved otherwise. this sometimes leads to unwarranted delay in correct diagnosis and management if there is ignorance regarding other rarer etiologies. rosai-dorfman disease (rdd) may present in the same manner and should always be kept on the back of the mind to help a...

COVID-19 is a viral infection and its prevalence requires investigation of different co-morbid conditions including tuberculosis, as well operation temporary infectious diseases hospitals (TIDH) for the treatment deployed on facilities anti-tuberculosis institutions. The objective : analysis follow-up patients with in institutions, assessment impact various medications methods patient lethality...