The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab...

Thrombopoietin (Tpo), the ligand for the c-Mpl receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo raises the platelet count fourfold within a few days. Conversely, c-mpl knock-out mice have platelet counts that are 15% that of normal. The subunit structure of the c-Mpl receptor is not fully understood. Some cytokines that stimulate megakaryopoiesis (IL-6, IL-11, leuk...

BACKGROUND/AIM Vitiligo is a common depigmenting disorder. The damage can also occur in similar ways to melanocytes within other organs. We evaluated the brainstem and auditory pathway functions by evaluating brainstem auditory evoked potentials (BAEPs) and whether there is any relationship between auditory functions and autoimmunity. MATERIALS AND METHODS Forty patients with vitiligo and 20 ...

Thyroid peroxidase (TPO) was purified from each thyroid of 10 patients (experiment 1) and 4 patients (experiment 2) with toxic diffuse goiter by a simplified method with monoclonal anti-TPO antibody-assisted immunoaffinity column chromatography. The final preparations were used to measure the heme concentration based on the cyanide difference spectrum, and to determine the Km and kcdt values fr...

In this study, we demonstrate that human umbilical cord vein-derived endothelial cells (HUVECs) expressed c-Mpl, the thrombopoietin (TPO) receptor, and that TPO activates HUVECs in vitro, as indicated by directional migration, synthesis of 1-alkyl-/1-acyl-platelet-activating factor (PAF) and interleukin-8 (IL-8), and phosphorylation of the signal transducers and activators of transcription (STA...

one of the most common endocrine disorders in women of reproductive age is polycystic ovary syndrome (pcos) which its prevalence is reported around 6.5-8% (1). some clinical trials assessed association between pcos and other autoimmune related endocrinopathies such as impaired glucose tolerance (igt), type 2 diabetes mellitus and thyroid dysfunction with controversial results (2). some investig...

Background and Aim: Spontaneous abortion is the most common pregnancy complication with no reasonable causes in most cases. Some research imply the role of anti-thyroid antibodies (e.g. anti TPO-Ab and anti TG-Ab) that can cause spontaneous abortion. In the present study, the association between abortion and presence of antithyroid antibodies in mother’s serum was assessed. Methods: In this cas...