Case presentation: We conducted a descriptive study of 4 cases with GLUT1 Deficiency (Glut1D) diagnosed in our service the past 2 years. The diagnosis was established by: hypoglycorrhachia, clinical symptoms and SLC2A1 mutation. Our first patient, 4-year-old boy, presented developmental delay, hypotonia, myoclonic jerks drop attacks at 11 months age. MRI brain image showed bilateral hippocampal...

Voltage-gated potassium channel complex antibodies, particularly those directed against leucine-rich glioma inactivated 1, are associated with a common form of limbic encephalitis that presents with cognitive impairment and seizures. Faciobrachial dystonic seizures have recently been reported as immunotherapy-responsive, brief, frequent events that often predate the cognitive impairment associa...

Epilepsy is a common neurologic disorder affecting about 1% of the population. 1 The prevalence of active epilepsy in Kerman is 7.87/1000. 2 In 23 countries of Asia the rate of epilepsy is the same as USA and Europe. Pharmacotherapy with antiepileptic drugs is the major treatment modality for epilepsy. This treatment could be a result of decreased excitation concurrent with increased inhibition...

.........................................................................................................................xi I. GENERAL INTRODUCTION .........................................................................................1 A. Epilepsy ................................................................................................................1 B. Current treatments of epileps...

Levetiracetam (LEV) is an anti-epileptic drug commonly used for the treatment of partial onset and generalized seizures. In addition to its neuromodulatory and neuroinhibitory effects via its binding to the synaptic vesicle protein SV2A, multiple studies have suggested neuroprotective properties for LEV in both epileptic and non-epileptic conditions. The purpose of this review is to discuss the...

Parenteral injection of kainic acid (KA), a glutamate receptor agonist, causes severe and stereotyped behavioral convulsions in mice and is used as a rodent model for human temporal lobe epilepsy. The goal of this study is to examine the potential anti-convulsive effects of the neuro-active amino acid taurine, in the mouse model of KA-induced limbic seizures. We found that taurine (43 mg/Kg, s....

A 47-year-old man presented with tonic-clonic seizures characterized by convulsions. He repeatedly exhibited despite treatment four anti-seizure medications. During the titration process of perampanel (PER), paradoxically increased in intensity and frequency, resulting trauma. Video electroencephalogram monitoring revealed interictal rapid rhythms generalized spikes documented atonic seizures. ...

pilepsy is a group of heterogeneous neurological disorders characterized by spontaneous and recurrent seizures and is one of the most common that affects 1% of the E Background & Objective: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequat...

Primary antiphospholipid syndrome (APS) is an autoimmune disease defined by vascular thrombosis, pregnancy complications, and persistent antiphospholipid antibodies. Neurological manifestations include stroke, seizures, and chorea among others. Seizures are often precipitated by an acute ischemic event, but occasionally, structural abnormalities are absent. We present a 61-year-old man who deve...

background: tramadol is a synthetic analgesic. seizures have been reported in patients receiving this drug. in this study we evaluated the correlation between tramadol consumption and seizure occurrence. methods: twenty-eight subjects with a history of tramadol consumption and seizure were studied. electroencephalograms (eeg) were performed in the first 24 hours and again one week later. subjec...