Piperine (1-peperoyl piperidine) was isolated from Piper nigrum Linn for the evaluation of anti-inflammatory activity in rats. Different acute and chronic experimental models like carrageenin-induced rat paw edema, cotton pellet granuloma, and croton oil-induced granuloma pouch, were employed. Simultaneously, biochemical estimations were made to elucidate the underlying mechanism of the action....

Hydroxydihydrocarvone (HC) is a synthetic intermediate obtained by hydration of the natural compound (R)-(-)-carvone. The aim of the present study was to investigate the possible anti-inflammatory activity of orally administered HC. Toxicity, motor coordination, tail immersion test, as well as carrageenan-induced paw edema and myeloperoxidase (MPO) activity or peritonitis were all evaluated in ...

background: inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. herbs have been traditionally used as anti-inflammatory agents since very early times. rubia tinctorum l. is one of these herbs that havebeen used for treating inflammatory diseases in iranian traditional medicine. objective: this study aims at co...

The present study was designed to assess the cytotoxicity, anti-inflammatory and analgesic properties of methanol extract of Woodfordia fruticosa flowers. Cytotoxic activity of methanol extract of Woodfordia fruticosa flowers was tested using Artemia salina (Brine shrimp) bioassay. Two doses (400 and 600 mg/Kg) were evaluated for the anti-inflammatory activity against the carrageenan, histamine...

1. Assistant Professor of Pharmacology, Bahria University Medical & Dental College, Karachi. 2. Assistant Professor of Pharmacology, Bahria University Medical & Dental College, Karachi. 3. Professor of pharmacology, United Medical & Dental College, Karachi 4. Professor of Pharmacology, Bahria University Medical & Dental College, Karachi. ABSTRACT... Objective: To evaluate anti-inflammatory acti...

Non-steroidal anti-inflammatory drugs play a major role in pain management. This article discusses the synthesis of thio-Pyrimidine, Benzoxazole, Benzothiazole and Triazole Analogues from Baylis-Hillman Bromides and their in-vitro testing for the activity of cyclooxygenase (COX) inhibition. The results are very encouraging and we can proceed for further investigations regarding their safety, in...

A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

Curcuma aromatica Salisb. is a precious medicinal herb with proven uses such as antibacterial, antioxidant, anti-inflammatory, anti-cancer abilities, etc. This study aims to evaluate the effects of extracts from rhizome C. collected in Yen Bai province for antibacterial and antioxidant activities. The results showed that ethanol aromaticaSalisb. had strong activity against three strains Staphyl...

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...