National Institute of Allergy and Infectious Diseases has classified all the emerging infectious diseases agents under three categories. Among Category A priority pathogens comes Bacillus anthracis -the causative agent of Anthrax. It is a gram positive spore bearing bacteria, and the disease is typically associated with grazing animals, and affects the people as a zoonosis. The disease can be c...

Bacillus anthracis is the causative agent of anthrax, a bacterial infection with a high mortality rate [1-3]. Although anthrax infection can be cutaneous, gastrointestinal or pulmonary, the pulmonary form is the most deadly [2,3]. Thus, the release of Bacillus anthracis spores that can be inhaled represents a potent bioterrorism threat; the capacity of B. anthracis spores to act as a bioterrori...

In the United States, Bacillus anthracis is a select agent and is subject to select agent requirements under the U.S. Code of Federal Regulations.* On April 20, 2015, samples of B. anthracis spores considered inactivated were shipped from a U.S. Department of Defense (DoD) laboratory at Dugway Proving Ground, Utah, to various laboratories for routine collaborative diagnostics research. On May 2...

Background: Anthrax is a particularly dangerous infectious disease that affects humans and livestock. Efficacious vaccines that can rapidly induce a long-term immune response are required to prevent anthrax infection in humans. Domains 4 and 1 of the protective antigen (PA) and lethal factor (LF), respectively, have very high antigenic properties. Aims: In this...

Between 1962 and 1971, six outbreaks of anthrax occurred in the bison herds of the Northwest Territories and northern Alberta. In response, the federal Health of Animals Branch dispatched staff veterinarians to oversee carcass disposal operations and later to take part in bison depopulation and vaccination programs. Recently, a collection of documents from that agency concerning the outbreaks w...