Squire et al. (1) recently asserted that patients with bilateral hippocampal damage can imagine future experiences. This contradicts a number of previous reports where amnesia and bilateral hippocampal lesions have been found to cause significant impairment in imagining fictitious and future scenarios (2–4). Based on their findings, Squire et al. (1) concluded that the capacity for imagining th...

Korsakoff syndrome (KS) is a neurological state mostly caused by alcohol-dependence and leading to disproportionate episodic memory deficits. KS patients present more severe anterograde amnesia than Alcohol-Dependent Subjects (ADS), which led to the continuum hypothesis postulating a progressive increase in brain and cognitive damages during the evolution from ADS to KS. This hypothesis has bee...

Previous studies using the process dissociation and the remember-know procedures led to conflicting conclusions regarding the effects of anterograde amnesia on recollection and familiarity. We argue that these apparent contradictions arose because different models were used to interpret the results and because differences in false-alarm rates between groups biased the estimates provided by thos...

The case of a 36-year-old man who suffers dense retrograde and anterograde amnesia as a result of closed-head injury that caused extensive damage to his left frontal-parietal and right parieto-occipital lobes is described. Patient K.C. has normal intelligence and relatively well-preserved perceptual, linguistic, short-term memory, and reasoning abilities. He possesses some fragmentary general k...

Based on a study using a retrograde neurotracer, we have previously found that the dorsal portion of the L5/6 disc in the rat is multisegmentally innervated by dorsal root ganglia (DRG) from the level of T13 to L6, and that sensory nerve fibres from DRG of T13, L1 and L2 pass through the paravertebral sympathetic trunks. In this study in newborn rats, we injected crystals of 1,1'-dioctadecyl-3,...

A 58-year-old man with coronary disease presented with headache, confusion, and vision loss. On examination, he had retrograde and anterograde amnesia, superior homonymous quadrantanopias, and could not identify colors. MRI showed bilateral occipital infarcts involving the parahippocampal and lingual gyri (figure 1). CT angiography revealed a hypoplastic vertebrobasilar circulation, with a pers...

The priming of patterns was examined in normal control subjects (NCS) and in the amnesic patient H.M., whose anterograde amnesia followed bilateral medial temporal-lobe excision 33 years earlier. Despite H.M.'s impaired recognition of the patterns, he demonstrated a pattern priming effect equivalent in magnitude to that of the NCS. The results demonstrated that intact priming with novel, nonver...

Background: Transient global amnesia (TGA) is a syndrome characterised by a sudden inability to form new memories (anterograde amnesia) and is not associated with any other focal neurological deficit. Various precipitating causes have been reported in the medical literature. No particular treatment is required. Case Report:A case of a 52-year-old man who presented to the emergency department wi...

There is controversy regarding the effect of isolated fornix damage on human memory. We report a patient who suffered a traumatic penetrating head injury that resulted in a significant and persistent anterograde amnesia. CT revealed a lesion that involved the region of the proximal, posterior portion of both fornices without evidence of damage to other hippocampal pathways or to other structure...

This case report describes the anesthetic management of a 67-year-old who underwent a catheter based pulmonary vein isolation (PVI) of long-standing, persistent atrial fibrillation. When the patient awoke from the 6.5 hour procedure, he was found to have a transient retrograde and anterograde amnesia that persisted for 18-24 hours postoperatively. This is a unique instance of global amnesia fol...