نتایج جستجو برای: animal pain
تعداد نتایج: 447853 فیلتر نتایج به سال:
the involvement of supraspinal alpha-adrenergic receptors in tonic pain was assessed in formalin-induced pain in rats. the alpha2 adrenoceptor agonist clonidine, along with yohimbine and prazosin, α2 and α1 receptor antagonists, were introduced intracerebroventrically (icv) and/or systemically in different doses. the data show that 1) clonidine exerts an alpha adrenergic analgesic effect, in ad...
Background and objectives: Non steroidal anti inflammatory drugs (NSAIDs) are widely used to reduce inflammation, pain and fever. The present study was organized to induce an experimental inflammation in an animal model, using a putative biological oxidant, Peroxynitrite (ONOO-) and to study the effects of Flunixin meglumine and Ketoprofen on the pressure-induced pain. Materials and Methods: Fo...
In the last two decades, animal models have become important tools in understanding and treating pain, and in predicting analgesic efficacy. Although rodent models retain a dominant role in the study of pain mechanisms, large animal models may predict human biology and pharmacology in certain pain conditions more accurately. Taking into consideration the anatomical and physiological characteris...
هدف: در این مطالعه به بررسی میزان فراوانی درد قفسه سینه در هفته نخست پس از انفارکتوس میوکارد در بیماران دیابتی مراجعه کننده به بیمارستان های آموزشی دانشگاه آزاد اسلامی طی سال های 89-1388 پرداختیم.روش مطالعه: این مطالعه به صورت یک بررسی مشاهده ای (observational) از نوع توصیفی (descriptive) مقطعی (cross-sectional) انجام شده است. حجم نمونه مورد بررسی شامل 84 بیمار دیابتی مبتلا به انفارکتوس میوکارد...
Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such models represent an important area for application of the 3Rs (replacement, reduction and refinement of animal use). Th...
Pain in animals is a welfare concern and it is therefore important to minimize the prevalence of pain in our cattle herds. A prerequisite for alleviating pain is the ability to recognize it. In many animal welfare protocols, pain is assessed through measuring conditions that are believed to be related to pain, e.g. wounds or lameness. More direct measures of pain have traditionally relied on ph...
as an animal that seeks pleasure and avoids pain. In this book Dr. Reik stresses the social type of masochism which tends to dominate not only the life of individuals but also social groups. His studies of the perverseness of the individual and of the behaviour of national groups forces him to the conclusion that, far from being a creature that seeks pleasure and avoids pain, man is indubitably...
BACKGROUND Pain is influenced by weather changes under certain circumstances, and inflammatory pain in animal models is ameliorated by pressure, but the underlying mechanism of atmospheric pressure has not been clearly elucidated. OBJECTIVE To examine the effect of pressure on pain in an arthritic animal model. STUDY DESIGN Controlled animal study. SETTING Laboratory animal study. METHO...
INTRODUCTION Degeneration of the interverterbral disk is as a cause of low-back pain is increasing. To gain insight into relationships between biological processes, structural alterations and behavioral pain, we created an animal model in rats. METHODS Disk degeneration was induced by removal of the nucleus pulposus (NP) from the lumbar disks (L4/L5 and L5/L6) of Sprague Dawley rats using a 0...
The assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets. This review will focus on knee joint pain associated with arthritis. Different animal models have been developed for the study of knee joint arthritis. Behavioral tests in animal models of knee joint arthritis typically measure knee joint pain rather indirectly. In recent year...
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