Pseudoxanthoma Elasticum is an inherited disorder characterized by generalized fragmentation and progressive calcification of the elastic tissues in the dermis, blood vessels and Bruch’s membrane of the eye. Herein, we report 3 patients in a family with pseudoxanthoma elasticum: a father and his two sons.

PURPOSE To report the visual outcome of photodynamic therapy (PDT) combined with intravitreal triamcinolone acetonide (IVTA) for choroidal neovascularization (CNV) secondary to angioid streaks (AS). METHODS Five eyes of five consecutive patients (mean age 45 +/- 10 years) with CNV secondary to AS were treated by combination of PDT and IVTA. TA (4 mg/0.1 mL) was injected 7 days before PDT. R...

Background: The purpose of this study is to determine the incidence of angioid streak-associated choroidal neovascular membranes (CNV) in the UK and provide other epidemiological data, clinical characteristics, therapies used, and short-term outcomes following treatment of this condition. Procedure: This is a prospective multicenter cohort study. Patients newly diagnosed of angioid streaksassoc...

BACKGROUND To report a patient with angioid streaks (ASs) and coincident multiple evanescent white dot syndrome (MEWDS) who developed choroidal neovascularization (CNV). CASE PRESENTATION A 20-year-old woman presented with reduced vision (20/100) in her left eye (LE). Based on a complete ophthalmologic examination the patient was diagnosed with ASs and coincident MEWDS. Two weeks later best-c...

The aim of this study is to report clinical course of choroidal neovascularization secondary to angioid streaks (AS) in two patients who underwent intravitreal bevacizumab therapy. Fundus examination, fluorescein angiography (FA) and optical coherence tomography (OCT) revealed the diagnosis of subfoveal classic choroidal neovascularization (CNV) in the right eye in patient 1 and in the left eye...

Background and aimsPseudoxanthoma elasticum (PXE) is caused by variants in the ABCC6 gene. It results calcification skin, peripheral arteries eyes, but has considerable phenotypic variability. We investigated association between genotype clinical phenotypes these different organs.MethodsABCC6 sequencing was performed 289 PXE patients. Genotypes were grouped as two truncating, mixed, or non-trun...

BACKGROUND The following case series describes the long-term anatomical and functional outcome of a group of seven patients with choroidal neovascularization (CNV), secondary to angioid streaks (AS), who were treated with antiangiogenic drugs in a pro re nata (PRN) regimen. After the 4-year mark, visual acuity tends to return to pretreatment level. Treatment delays and lack of awareness and sel...