Different epithelial organs form as a result of epithelial-mesenchymal interactions and share a common theme modulated by variations (Chuong ed. In Molecular Basis of Epithelial Appendage Morphogenesis, 1998). One of the major modulators is the sex hormone pathway that acts on the prototype signaling pathway to alter organ phenotypes. Here, we focus on how the sex hormone pathway may interface ...

The epididymis is an androgen-sensitive tissue which responds to even minor fluctuations in circulating androgens (Prasad, Rajalakshmi, Gupta & Karkun, 1973). Epididymal receptors for androgens have been demonstrated (Blaquier, 1971) and male sex hormones are required for epididymal growth and structural and functional maintenance (Benoit, 1926; Risley, 1963 ; Price & Ortiz, 1965). Apart from c...

OBJECTIVE Despite widespread abuse of anabolic-androgenic steroids (AAS), the endocrine effects of supraphysiologic doses of these compounds remain unclear. We administered the AAS methyltestosterone (MT) to 20 normal volunteers in an in-patient setting, examined its effects on levels of pituitary-gonadal, -thyroid, and -adrenal hormones, and examined potential relationships between endocrine c...

Hormones excreted in animal waste have been measured in surface and groundwater associated with manure that is applied to the land surface. Limited studies have been done on the fate and transport of androgenic hormones in soils. In this study, batch and column experiments were used to identify the fate and transport of radiolabeled [14C] testosterone in agricultural soils. The batch results in...

background: diazinon (dzn) is an organophosphorate synthetic insecticide widely used in agriculture. dzn has been observed to cause many changes, such as alterations in androgenic hormones. in the present study, the effect of dzn treatment on the structure of the testes and spermatogenesis in young adult albino rats was evaluated. materials and methods: adult rats were randomly divided into thr...

Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately should be used as an opportunity to educate both athletes and the general populati...

The steroidogenic acute regulatory protein (StAR) is a vital mitochondrial protein that is indispensable for the synthesis of steroid hormones in the steroidogenic cells of the adrenal cortex and the gonads. Recent studies have shown that StAR enhances the conversion of the substrate for all steroid hormones, cholesterol, into pregnenolone, probably by facilitating cholesterol entry into the in...

Cognitive abilities, such as verbal fluency and mental rotation, are most sensitive to changes in sex steroids but poorly studied in the context of hormonal contraceptive usage. Therefore, we investigated the performance of mental rotation and verbal fluency in young (21.5±1.8 years) healthy oral contraceptive (OC) users (23 women) and non-users (20 women) during the follicular, ovulatory and l...