Supplementation has beneficial effects in immune system and can antioxidant enzymes activity increases during the exercise and protects the tissue against the oxidative stress. L-Carnitine is a famous Supplement and helps to protect against the oxidative stress during and after intense or prolonged exercise. The aim of this study was to investigate the effect of L-Carnitine supplementation on t...

Soil salinity is one of the major abiotic stresses that adversely affect plant productivity and quality. Therefore, an experiment was conducted to investigate the effects of seed treatment with L-arginine on some morphological and physiological parameters of Brassica napus under salinity stress. The seeds of canola were pre-treated with three arginine concentrations (0, 5, and 10µM Arg) for 24 ...

The objective of this study was to determine the protective effect of glutamate (Glu) in Cu-induced oxidative injury in fish intestine in vivo and enterocytes in vitro. The results indicated that exposure to 6 mg/l Cu for 72 h induced the production of reactive oxygen species, thereby increasing protein oxidation and lipid peroxidation in enterocytes of grass carp in vitro. Cells exposed to Cu ...

The 12-lipoxygenase pathway of arachidonic acid metabolism in platelets and other cells is bifurcated into a reduction route yielding 12-hydroxyeicosatetraenoic acid (12-HETE) and an isomerization route forming hepoxilins. Here we show for the first time the presence of phospholipid hydroperoxide glutathione peroxidase (PHGPx) protein and its activity in platelets. The ratio of the activity of ...

Fluoxetine is an antidepressant widely used to treat depressive and anxiety states. Due its mode of action in the central nervous system (selective serotonin reuptake inhibitor (SSRI)), it becomes toxic non-target organisms, leading changes that are harmful their survival. In this work, effects fluoxetine on juvenile zebrafish (Danio rerio) were evaluated, assessing biochemical (phase II biotra...

The neuroendocrine functions of the pineal affect a wide variety of glandular and nervous system processes. Beside melatonin (MEL), the pineal gland secretes and expresses certain proteins essential for various physiological functions. It has been suggested that the pineal gland may also have an antioxidant role due to secretory product other than MEL. Therefore, the present study was designed ...

In ethnomedicine, the leaf of S. anomalum is used to treat a variety illnesses, including diabetes. The goal this study was assess effects extract and fractions on kidney function indices, renal histology, indicators oxidative stress in rats with diabetes caused by alloxan. Antioxidative renoprotective potentials (70-210 mg/kg) (140 were assessed determining markers levels, parameters histopath...

Recently, we have put forward the hypothesis that a decreased concentration of reduced glutathione (GSH) may be implicated in the mechanisms of peroxidative damage to the liver and kidney caused by lead (Pb) and/or ethanol (EtOH). Thus, the aim of the present study was to assess the activities of GSH-related enzymes, such as glutathione peroxidase (GPx), glutathione reductase (GR), and glutathi...

Today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-ZrO2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. However, there are some reports implying that use of nano-ZrO2 is associated with cytotoxic effects like inhibiting the cell proliferation, DNA damage and apoptosis. In the present study, we examined whether nano-ZrO2 alters ...