Allogeneic bone marrow transplantation (BMT) is a common treatment of hematologic malignancies. Recurrence of the underlying malignancy is a major cause of treatment failure. Donor-derived cytotoxic T lymphocytes (CTLs) specific for patients' minor histocompatibility antigens (mHags) play an important role in both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) reactivities. mH...

Materials Sodium form of hyaluronic acid (HA, MW, 10 kDa) was a gift of Kolon Life Science, Korea. EDC.HCl (99%) and N-Hydroxy succinimide (NHS, 99%) were purchased from Shanghai Medeep Co., Ltd. Monostearin (glycerol α-monostearate, GMS), Sodium deoxycholate (DOC) and fluorescein isothiocyanate (FITC) were purchased from Solarbio (Beijing, China). Doxorubicin hydrochloride (DOX) was supplied b...

Chickpea (Cicer arietinum L.) is one of the major legume crops grown in Pakistan having a considerable importance as a food, feed and fodder but due to imbalanced use of fertilizers its production is low. To find the optimum level of Phosphorus and FYM for chickpea and study their effect on agronomic characteristics an experiment was carried out at the Agricultural Research Farm of NWFP Agricul...

Hyperthermia-induced hyperventilation has been proposed to be a human thermolytic thermoregulatory response and to contribute to the disproportionate increase in exercise ventilation (VE) relative to metabolic needs during high-intensity exercise. In this study it was hypothesized that VE would adapt similar to human eccrine sweating (E(SW)) following a passive heat acclimation (HA). All partic...

Adoptive transfer of antigen-specific T cells is an attractive strategy for the treatment of hematologic malignancies. It has been shown that T cells recognizing minor histocompatibility antigens (mHag) selectively expressed on hematopoietic cells mediate antileukemic reactivity after allogeneic stem cell transplantation. However, large numbers of T cells with defined specificity are difficult ...

in order to studying the effect of conventional fertilization and organic fertilizeron growth, yield and nitrate accumulation of spinach, a greenhouse experiment was carried out in factorial based on random complete design with three replications in a commercial greenhouse located at lahijan. treatments were three levels of municipal soil waste compost (0, 50 and 100 t ha-1), five chemical fert...

The memory T cell response is polyclonal, with the magnitude and specificity of the response controlled in part by the burst size of T cells expanded from effector/memory precursors. Sensitive assays using HLA class II multimers were used to detect low-frequency Ag-specific T cells directed against influenza viral Ags in subjects immunized with the influenza vaccine. Direct ex vivo tetramer sta...

In order to study the effect of different levels of the manure and foliar application of Zn and Mn fertilizers on the quantitative and qualitative yield of soybeans (var. Williams), a factorial experiment was conducted in a randomized complete block design with three replications in 2012. Treatments involved three levels of fertilizer: manure (zero as control; six and 12 t/ha), two lev...