AMA Chodkiewicz J, Morawska K, Łukowska K. Research into alcohol-dependent persons in treatment during the COVID-19 pandemic. Part two – role of pandemic and its consequences. Alcoholism Drug Addiction/Alkoholizm i Narkomania. 2022;35(4):249-270. doi:10.5114/ain.2022.126579. APA Chodkiewicz, J., Morawska, K., & Łukowska, (2022). Narkomania, 35(4), 249-270. https://doi.org/10.5114/ain.2022.12657...

Chronic lymphocytic leukemia of B-cell origin (B-CLL) is generally thought to arise by neoplastic transformation of B lymphocytes, which express CD5 and have features of an early stage of B-cell differentiation. To study isotype-switched B-CLL as a potentially more differentiated variant, we performed genetic and functional immunoglobulin (Ig) gene analysis in two cases of CD5+ B-CLL in which t...

Populations of the common bed bug, Cimex lectularius, have recently undergone explosive growth. Bed bugs share many important traits with triatomine insects, but it remains unclear whether these similarities include the ability to transmit Trypanosoma cruzi, the etiologic agent of Chagas disease. Here, we show efficient and bidirectional transmission of T. cruzi between hosts and bed bugs in a ...

Aflatoxin B1 (AFB1) contamination in the food chain is a major cause of hepatocellular carcinoma (HCC). More than 60% of AFB1 related HCC carry p53 codon 249 mutations but the causal mechanism remains unclear. We found that 1) AFB1 induces two types of DNA adducts in human hepatocytes, AFB1-8,9-epoxide-deoxyguanosine (AFB1-E-dG) induced by AFB1-E and cyclic α-methyl-γ-hydroxy-1,N2-propano-dG (m...

p53 mutations are common in lung cancer. In smoking-associated lung cancer,the occurrence of G:C to T:A transversions at hotspot codons, e.g., 157, 248, 249,and 273, has been linked to the presence of carcinogenic chemicalsin tobacco smoke including polycyclic aromatic hydrocarbons suchas benzo(a)pyrene (BP). In the present study, we have used a highly sensitive mutation assay to determine the ...

On Leg 25 of the Deep Sea Drilling Project five holes penetrated basement, and a total of approximately 12.7 meters of basalt were recovered. We have measured compressional and shear wave velocities to hydrostatic pressures of 6 kb in representative samples of basalt from each hole and a relatively high density limestone from Site 249. In addition, compressional wave velocities are reported for...

OBJECTIVES This case-control study was done to determine the association and prevalence of p53 codon 249 mutation using cell-free DNA in the plasma of patients with hepatocellular carcinoma (HCC) in South-Western Nigeria. METHOD Eighty-five adults with HCC and seventy-seven age and gender matched controls without evidence of liver disease or malignancy involving any part of the body, were rec...