Liquid flow from a column is nebulised using nitrogen or air to give a plume of fine droplets containing the analyte in solution. The liquid droplets pass into a heated zone where the solvent is removed to leave the dried analyte particle which is subsequently irradiated with light. The amount of light scattered is then measured. Gas flow and temperature can be adjusted to optimise the response...

Derivatization reactions are meant to transform an analyte for detectability in Gas Chromatography (GC) or other instrumental analytical methods. Derivatization in GC analysis can be defined as a procedural technique that primarily modifies an analyte’s functionality in order to enable chromatographic separations. A modified analyte in this case will be the product, which is known as the deriva...

We describe a dual-core microstructured optical fiber designed for refractive index sensing of fluids. We show that by using the exponential dependence of intercore coupling on analyte refractive index, both large range and high sensitivity can be achieved in the one device. We also show that selective filling of the microstructure with analyte can increase the device sensitivity by approximate...

A leading application of biomolecular interaction analysis technology is the characterization of antibodyantigen interactions. By measuring the association and dissociation rates of the interaction, antibodies with desired binding characteristics can be identified. A rapid association rate and a slow dissociation rate may be indicative of therapeutic efficacy. Affinity maturation programs exist...

Depositing very thin organic films on the surface of arrays of asymmetric split-ring resonators (A-SRRs) produces a shift in their resonance spectra that can be utilized for sensitive analyte detection. Here we show that when poly-methyl-methacrylate (PMMA) is used as an organic probe (analyte) on top of the A-SRR array, the phase and amplitude of a characteristic molecular Fano resonance assoc...

We demonstrate a composite nanomaterial, termed an aptamer nano-flare, that can directly quantify an intracellular analyte in a living cell. Aptamer nano-flares consist of a gold nanoparticle core functionalized with a dense monolayer of nucleic acid aptamers with a high affinity for adenosine triphosphate (ATP). The probes bind selectively to target molecules and release fluorescent reporters ...

A new procedure is provided for transferring analyte concentration values from a reference material to production calibrators. This method is robust to calibration curve-fitting errors and can be accomplished using only one instrument and one set of reagents. An easily implemented stochastic approximation algorithm iteratively finds the appropriate analyte level of a standard prepared from a re...