The aim of this study was to investigate the effect of treatment of experimental ovarian cancers with targeted cytotoxic analogs as single compounds and in combination. Targeted cytotoxic analogs of bombesin (AN-215), somatostatin (AN-238), and luteinizing hormone-releasing hormone (AN-207) consisted of 2-pyrrolinodoxorubicin (AN-201) linked to the respective peptide carrier. AN-238 at 200 nmol...

In searching for macromolecular antitumor antibiotics of microbial origin, 2,875 kinds of Actinomycetes culture fluids were applied to a newly developed test system which consisted of antimicrobial assay using a macromolecule permeable mutant, DNA damage assay and mutagenicity test. As a result, 78 macromolecular antibiotics were found. Among them, 15 antibiotics precipitable with ammonium sulf...

A byproduct of experiments designed to map the CMB is the recent detection of a new component of foreground galactic emission. The anomalous foreground at 10-30 GHz, unexplained by traditional emission mechanisms, correlates with 100 mum dust emission, and is thus presumably due to dust. Is the anomalous foreground ubiquitous in the Galaxy? I will present evidence obtained with the CBI and SIMB...

The non-uniqueness of geodesics joining two given points in universal Teichm uller space is proved in the previous paper 7]. The purpose of the present paper is to discuss the non-uniqueness of geodesics in any innnite-dimensional Teichm uller space. It is proved that if 1 and 2 are two extremal Beltrami diierentials belonging to a point ] of a Teichm uller space and 1 ? 2 does not belong to N-...

In this paper, we apply the fuzzy linear regression (FLR) with fuzzy intervals analysis into a neural network classi®cation model. The FLR works as a data handler and separates the data sample into two groups. By training two independent neural works with these two groups, we can better describe the distribution space of the corresponding data sample with two different functions, rather than us...