The appetite suppressant dexfenfluramine, which inhibits neuronal 5-HT uptake and elevates plasma 5-HT levels, has been associated with an increase in the relative risk of developing primary pulmonary hypertension. 5-HT is a mitogen for pulmonary artery smooth muscle cells (PA-SMCs), an effect that depends upon activity of the 5-HT transporter (5-HTT). To investigate the relationship between de...

RNA ISH (Ribonucleic acid in situ hybridization) assays are an ever-expanding application due to the ability to evaluate molecular targets with the added benefit of retaining tissue morphology. The rate limiting step in RNA ISH assays is the time consuming and error prone method of manually counting signal when reviewing under a microscope. The Aperio RNA ISH algorithm offers a reproducible, fa...

pon differentiation, many cell types no longer proliferate in response to growth factor–activated MAPK. But MAPK has more than just mitogenic effects, and the cells must still activate and respond to MAPK to adjust lipid metabolism, protein synthesis, and other cellular functions. On page 689, Smith et al. identify a simple, yet until now elusive, mechanism by which cells uncouple MAPK's prolif...

This book is dealing with some approaches to analysis of specific social networks called company networks. These company networks emerge from interactions between companies, where a lot of these interactions are recorded by publicly accessible sources. Our work is designing and implementing methods of heterogeneous sources’ cleansing, aggregation and integration into comprehensive data model of...

The neo-Fregean project of basing mathematics on abstraction principles faces “the bad company problem,” namely that a great variety of unacceptable abstraction principles are mixed in among the acceptable ones. In this paper I propose a new solution to the problem, based on the idea that individuation must take the form of a well-founded process. A surprising aspect of this solution is that ev...

A Final Word page 7 D espite the robust growth of the U.S. economy in the late 1990s, uncertainties in the global marketplace and changes in the economic and competitive environment have forced companies everywhere to reevaluate their current ways of doing business. Who could have predicted the rapid impact of e-technology on business? Who would have anticipated the effects of regional financia...

Craig Knight, Asia-Pacific Digital Business and Customer Services Manager of Eastman Chemical Company, was given a mandate to sell Eastman’s philosophy for an integrated electronic supply chain, otherwise known as the Integrated System Solution (ISS), to its business partners in the region, and to encourage adoption. Having invested in a state-of-the-art technical architecture that would suppor...

Classically, allergy depends on IgE antibodies and on high-affinity IgE receptors expressed by mast cells and basophils. This long accepted IgE/FcεRI/mast cell paradigm, on which the definition of immediate hypersensitivity was based in the Gell and Coomb's classification, appears too reductionist. Recently accumulated evidence indeed requires that not only IgE but also IgG antibodies, that not...