BACKGROUND Pain after amputation is common but difficult to treat, and few controlled treatment studies exist. METHODS In the current study, 94 treatment-naive posttraumatic limb amputees with phantom pain (intensity: mean visual analog scale score [0-100], 40 [95% confidence interval, 38-41]) were randomly assigned to receive individually titrated doses of tramadol, placebo (double-blind com...

The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD). Forty-seven women (mean age = 35.4 years old) with chronic TMD were enrolled in the study and divided into 4 groups: amitriptyline; amitriptyline and CBT; placebo and CBT; and placebo...

BACKGROUND Pain in the rectal, genital, and perineal area is a common condition treated by pain physicians. These chronic pain syndromes are therapeutically challenging because both interventional and drug therapies often are ineffective. OBJECTIVES To determine if pelvic pain can be treated effectively with compounded topical amitriptyline-ketamine. STUDY DESIGN A retrospective review of m...

A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combi...

a rapid, specific and accurate proton quantitative nuclear magnetic resonance spectroscopic (1h qnmr) and also a reversed phase derivatization hplc method have been developed to quantify a toxic, uv-visible inactive and non-volatile impurity n,n-dimethylamine hydrochloride (dma∙hcl) in metformin hydrochloride (mf∙hcl), an active pharmaceutical ingradient. the method is based on proton quantitat...

Publishing; 2004. p. 473-86. 5. Caksen H, Akbayram S, Odabaş D, Ozbek H, Erol M, Akgün C, et al. Acute amitriptyline intoxication: An analysis of 44 children. Hum Exp Toxicol 2006;25:107-10. 6. Wohlreich MM, Welch W. Amitriptyline abuse presenting as acute toxicity. Psychosomatics 1993;34:191-3. 7. Prahlow JA, Landrum JE. Amitriptyline abuse and misuse. Am J Forensic Med Pathol 2005;26:86-8. 8....

The cardiotoxicity of the tricyclic antidepressants amitriptyline and doxepin were compared in an animal with acute overdose. The mean repetitive extrasystole threshold (RET) decreased 71.5% with amitriptyline and 27.5% with doxepin (mean blood levels 933 ng/ml and 1889 ng/ml). Physostigmine reversed these effects. Sodium bicarbonate had a variable effect on the lowered RET. The toxic arrhythmo...

Aim: To compare the efficacy of amitriptyline, pregabalin and placebo in alleviating pain associated with diabetic peripheral neuropathy. Method: A total of 150 patients were randomly recruited for the study. Assessment for pain relief was carried out on an 11-point, Likert-like numeric rating scale [NRS]; 0= no pain” to 10=worst possible pain”) over a 7-day baseline period. Following a 1-week ...

BACKGROUND AND OBJECTIVES Tricyclic antidepressants (TCAs) are widely used as analgesics in chronic lumbar pain and neuropathic pain. The objective of this study was to evaluate the electrocardiographic changes in patients with chronic pain treated with amitriptyline or imipramine. METHODS Forty patients, ages 26 to 81 years (57.27 +/- 13.65 years) of both genders (female 19, male 21), with n...

BACKGROUND Interactions between the sympathetic and somatic nervous system play an essential role in the pathophysiologic mechanisms of neuropathic pain. The α2-adrenoceptor agonists produce effective antinociception, but sedation is an important adverse effect. Multidrug therapy is potentially valuable to decrease side effects. OBJECTIVE The aim of the present study was to investigate the po...