The amino acid glycine is involved not only in protein formation but in t,he synthesis of glutathione, creatine (l), and the protoporphyrin of hemoglobin (2). However, the mechanism by which the animal organism forms glycine is cluite obscure. It has been generally considered that the “nonessential” amino acids are synthesized from a-keto acids either by amination with ammonia or by transaminat...

Yeasts grown in the presence of benzoic acid tolerated 40 to 100% higher benzoic acid concentrations than did those grown in the absence of weak-acid-type preservatives. They also accumulated less benzoate in the presence of glucose. In chemostat cultures, benzoic acid reduced growth yield and the rate of cell production but increased specific fermentation rates. Benzoate contents were lower th...

Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C-H bond of benzoic acids or t...

The aim of this study is to estimate dietary intake of benzoic acid and its salts through food additives in adult population of South East Serbia. Information on dietary intake among 620 adults (aged 18-65) was collected using a food frequency questionnaire, and 748 food samples were analyzed. The mean estimated intake of benzoic acid -0.32 mg/kg of body weight (bw) per day was below acceptable...

Benzoic acid is oxidized by certain Mycobacteria (1). They do not oxidize it completely to carbon dioxide and water; the oxygen uptake usually stops when 5 atoms of oxygen are utilized for each molecule of benzoic acid. The enzymes concerned are adaptive, and are rapidly formed when small amounts of benzoic acid are added to suspensions of the bacteria (2). Benzoic acid may be considered somewh...

Certain Mycobacteriu form adaptive enzymes for the oxidation of benzoic acid (1). The oxidation proceeds through catechol and protocatechuic acid (2) and is thus similar to that in PseudomonasJEuorescens (3). Neither cyclohexanecarboxylic acid nor any substituted benzoic acid is oxidized by these Mycobacteria, but certain of these compounds can induce the organism to form adaptive enzymes for b...

The amino acid glycine is involved not only in protein formation but in t,he synthesis of glutathione, creatine (l), and the protoporphyrin of hemoglobin (2). However, the mechanism by which the animal organism forms glycine is cluite obscure. It has been generally considered that the “nonessential” amino acids are synthesized from a-keto acids either by amination with ammonia or by transaminat...

The monolayer-forming, human choriocarcinoma cell line, BeWo, was used to study the mechanisms of monocarboxylic acid transport across the human trophoblast. Benzoic acid, acetic acid, and lactic acid were used as markers for monocarboxylic acid carrier-mediated transport. The uptake of benzoic acid by BeWo cells was saturable (K(t) = 0.6 +/- 0.3 mM) at higher concentrations and significantly i...

A simple method for the simultaneous determination of hippuric acid and benzoic acid in urine using reversed-phase high performance liquid chromatography was described. Chromatography was performed on a Nova-Pak C18 (3.9 x 150 mm) column with a mobile phase of mixed solution methanol: water: acetic acid (20:80:0.2) and UV detection at 254 nm. The calibration curve was linear within concentratio...