نتایج جستجو برای: alveolar epithelial cells
تعداد نتایج: 1471191 فیلتر نتایج به سال:
Sepsis results in the formation of pulmonary edema by increasing in epithelial permeability. Therefore we hypothesized that alveolar epithelial cells isolated from septic animals develop tight junctions with different protein composition and reduced barrier function relative to alveolar epithelial cells from healthy animals. Male rats (200-300 g) were sacrificed 24 hours after cecal ligation an...
KL-6 is a pulmonary epithelial mucin more prominently expressed on the surface membrane of alveolar type II cells when these cells are proliferating, stimulated, and/or injured. We hypothesized that high levels of KL-6 in epithelial lining fluid and plasma would reflect the severity of lung injury in patients with acute lung injury (ALI). Epithelial lining fluid was obtained at onset (day 0) an...
1. Abstract 2. Introduction 3. Lessons from the inflammatory pathway 3.1. The paradigm of type 1 or type 2 cytokine network commitment 3.2. Chemokines 3.2.1. Chemokines in inflammatory/fibrotic lung disorders 3.2.2. Chemokines and Th1/Th2 cytokines circuit 3.2.3. Chemokines and angiogenesis 4. The epithelial pathway. Tying loose ends 4.1. Idiopathic pulmonary fibrosis and the alveolar epitheliu...
The non-small cell lung cancer is a common malignancy with high metastasis capacity. brain the primary site for patients unclear mechanism. Here, in this study, we hypothesized an innovative signaling cascade disorder and systematically investigated underlying Their differentially gene expression analysis was based on 13 conventional nonsmall 15 respectively. line, adenocarcinomic human alveola...
During extensive inflammation, neutrophils undergo secondary necrosis causing myeloperoxidase (MPO) release that may damage resident lung cells. Recent observations suggest that MPO has pro-inflammatory properties, independent of its enzymatic activity. The aims of the present study were to characterise MPO internalisation by lung epithelial cells and to investigate the effect of MPO on oxidati...
The ability of transforming growth factor-beta1 (TGF-beta1) to induce epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AEC) in vitro and in vivo, together with the demonstration of EMT in biopsies of idiopathic pulmonary fibrosis (IPF) patients, suggests a role for TGF-beta1-induced EMT in disease pathogenesis. We investigated the effects of N-acetylcysteine (NAC) on TGF-be...
BACKGROUND Microvesicles (MVs) are important mediators of intercellular communication, packaging a variety of molecular cargo. They have been implicated in the pathophysiology of various inflammatory diseases; yet, their role in acute lung injury (ALI) remains unknown. OBJECTIVES We aimed to identify the biological activity and functional role of intra-alveolar MVs in ALI. METHODS Lipopolys...
background: magnetized water has made many improvements in industry, agriculture and medicine. however its utilization in medicine still remains controversial. objective: in this study we aimed to investigate the effects of magnetized water on height of epithelial cells in pre-implantation stage endometrium and fallopian tube and number of corpus lutea in female mice. materials and methods: e...
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