IMPORTANCE The risk of congenital heart defects in infants of women who had preeclampsia during pregnancy is poorly understood, despite shared angiogenic pathways in both conditions. OBJECTIVE To determine the prevalence of congenital heart defects in offspring of women with preeclampsia. DESIGN, SETTING, AND PARTICIPANTS Population-level analysis of live births before discharge, 1989-2012,...

OBJECTIVES To evaluate the reproducibility and the accuracy of pediatric radiologists' assessments of chest radiographs with respect to the presence or absence of heart defects in children with an asymptomatic heart murmur. DESIGN Ninety-eight children, ages 1 month to 15 years (median, 30.1 months), referred for evaluation of a heart murmur were consecutively included. They all had a standar...

BACKGROUND Tumor necrosis factor-alpha (TNF) is increased in myocardial tissue after ischemia and reperfusion (I/R). TNF contributes to postischemic myocardial dysfunction and induces proinflammatory signaling, which may be mediated by the 55-kDa TNF receptor (TNFR1). In humans, there is a direct correlation between functional capacity, survival, and circulating TNF levels. Although decreasing ...

An estimated 276,000 babies die within four weeks of birth every year worldwide from congenital anomalies [2]. The most common severe congenital anomalies are heart defects, neural tube defects and Down Syndrome. Although congenital anomalies may be genetic, infectious, nutritional or environmental in origin, most often it is difficult to identify the exact cause [2]. In 2004, hospital costs in...

Clinical and experimental data have shown that after acute myocardial infarction there is a significant release of tumour necrosis factor alpha. Therefore, an attempt was made to correlate changes in serum tumour necrosis factor alpha concentrations with indices of infarct extent in patients with acute myocardial infarction. In 50 patients with acute myocardial infarction, blood samples for eva...

CONTEXT Few systematic data exist on survival and reproduction among males with birth defects and their contribution to occurrence of birth defects in the next generation. OBJECTIVE To estimate survival of males with registered birth defects, their subsequent reproduction rates, and their risk of transmitting birth defects to their offspring. DESIGN AND SETTING Population-based cohort study...

Congenital heart defects (CHD) are the most common types of major birth defects, leading cause infant morbidity and mortality. Syndromic babies more affected by CHD. This observational study was conducted in a tertiary care hospital military facility Bangladesh. Eighty syndromic neonates were studied through history, physical examination investigated for incidence risk factors Out 80 61(76.3%) ...