Use of musculoskeletal allografts has become increasingly popular, with widespread use among knee surgeons. The advantages and disadvantages of their use have been documented. In the knee, allografts are used for ligament reconstruction, meniscal transplantation, and articular surface reconstruction. The purpose of this review is to present issues surrounding the allograft industry, including r...

Sarcoidosis is a multisystem disorder of unknown aetiology characterized by the accumulation of lymphocytes, mononuclear phagocytes, and non-caseating granulomas in involved tissues. Renal involvement leading to renal function deterioration in sarcoidosis is rare: it is observed in <10% of patients. In the relevant literature, there have been only a few cases of sarcoidosis recurrence in renal ...

Dear Editor, High zinc level by promoting the immune system may cause rejection in the allograft organ. So it seems that limitation of zinc supplement and all foods and drugs with high amount of zinc may be effective in prevention of rejection after transplantation. Zinc is an essential micronutrient for human growth, development and immune function. Zinc deficiency was accompanied by the quali...

OBJECTIVE To determine whether kidney transplants performed during a weekend had worse outcomes than those performed during weekdays. DESIGN Retrospective national database study. SETTING United Network for Organ Sharing database of the USA. PARTICIPANTS 136,715 adult recipients of deceased donor single organ kidney transplants in the USA between 4/1994 and 9/2010. MAIN OUTCOME MEASURES...

OBJECTIVES We sought to use cardiac magnetic resonance (CMR) to establish sensitive and reliable indexes for noninvasive detection of acute cardiac allograft rejection. BACKGROUND Appropriate surveillance for acute allograft rejection is vitally important for graft survival. The current gold standard for diagnosing and staging rejection after organ transplantation is endomyocardial biopsy, wh...

BACKGROUND The CD40-CD40L (CD154) costimulatory pathway plays a critical role in the pathogenesis of kidney allograft rejection. In renal transplant biopsies, CD4+CD40L+ graft-infiltrating cells were detected during chronic rejection in contrast to acute rejection episodes. Using a rapid noninvasive FACS procedure, we were able to demonstrate CD40L upregulation in peripheral blood of patients w...

Kidney allograft rejection is associated with infiltration of inflammatory CD11b+ leukocytes. A CD11b agonist leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. Here, we test the extent to which LA1-mediated activation of CD11b/CD18 enhances kidney allograft survival in a mouse model of fully MHC-mismatched orthotopic kidney transpl...

CONTEXT Renal Transplantation is the most effective treatment for patients with end-stage renal disease, which is fortunately available in the developing countries, even for poor people. Nonetheless, the way forward should be the implementation of advanced science of transplantation, allograft monitoring abilities, knowledge about the epidemiology of renal disease in any specific region, awaren...