Carboplatin (CP) is the mainstay therapy in ovarian and testicular carcinoma. Several cases of allergic reactions to CP have been descr ibed? -3 Pre t rea tment with steroids and antihistamines did not prevent recurrent reactions. 1,3 A successful 4-hour desensitization protocol was documen ted in a single pa t i en t? We describe two patients allergic to CP who had recurrent reactions while un...

Allergy affects at least one-quarter of European schoolchildren, it reduces quality of life and may impair school performance; there is a risk of severe reactions and, in rare cases, death. Allergy is a multi-system disorder, and children often have several co-existing diseases, i.e. allergic rhinitis, asthma, eczema and food allergy. Severe food allergy reactions may occur for the first time a...

BACKGROUND Allergic sensitization and reactions to guinea pig (Cavia porcellus) have been well documented in laboratory animal handlers, primarily manifesting as rhinitis, conjunctivitis, and asthma. Severe allergic reactions, however, are rare. METHODS We report two patients with severe allergic reactions following non-occupational exposure to guinea pigs. The first patient, an 11-year-old f...

BACKGROUND Hen's egg is one of the main causes of food allergy in children. Accidental exposure is common in food-allergic patients. However, the few studies that analyze this problem focus mainly on peanut allergy. We sought to calculate the frequency of accidental exposure reactions in children allergic to hen's egg during a 12-month period, to analyze the clinical characteristics and circums...

The Allergology Hospital Network and Regional Register for Severe Allergic Reactions (Regional Observatory) is the Piemonte Health Authority new challenge. It satisfied the need to promote and monitor the best practice among a variegated pool of specialists and to define both state of the art and evolution of efficiency and efficacy of standard working process. Harmonization in clinical daily a...

Introduction Food allergic reactions are due to an immune response to specific food components, allergens, that are commonly glycoproteins or other proteins or, rarely, carbohydrates. The most frequent allergic reactions are immediate hypersensitivity reactions mediated by antibodies (IgE) to food allergens. These antibodies circulate in the blood and are unique in that they can attach to mast ...

Pseudo-allergic reactions may result from the activation of inflammatory or anaphylactic mechanisms independent of antigen-specific immune responses. Recent statistics show that pseudo-allergic reactions may represent as high as two thirds of all immediate hypersensitivity reactions, implying a great amount of morbidity and numerous health care costs. In this review, we concentrate on agents me...

BACKGROUND Allergic reactions to food are well recognized in both children and adults, but because of their relative infrequency their typical features may not be readily recognized by patients and their medical care givers who are not allergists. OBJECTIVE We sought to investigate the circumstances and clinical characteristics of food allergies in adults and children in the community. METH...

Introduction Adverse reactions to pharmaceutical and diagnostic products constitute a major hazard in the practice of medicine and are responsible for substantial morbidity and cost. Adverse drug reactions can be divided into predictable and unpredictable reactions. Predictable reactions including drug toxicity, drug interactions, and adverse effects are dose dependent, can be related to known ...