نتایج جستجو برای: ali and schaeffer function
تعداد نتایج: 16940905 فیلتر نتایج به سال:
Background: Intravenous salbutamol (albuterol) reduces lung water in patients with the acute respiratory distress syndrome (ARDS). Experimental data show that it also reduces pulmonary neutrophil accumulation or activation and inflammation in ARDS. Aim: To investigate the effects of salbutamol on neutrophil function. Methods: The in vitro effects of salbutamol on neutrophil function were determ...
Caveolin-1 (cav-1), a 22-kDa transmembrane scaffolding protein, is the principal structural component of caveolae. Cav-1 regulates critical cell functions including proliferation, apoptosis, cell differentiation, and transcytosis via diverse signaling pathways. Abundant in almost every cell type in the lung, including type I epithelial cells, endothelial cells, smooth muscle cells, fibroblasts,...
We present a bijection for toroidal maps that are essentially 3-connected (3-connected in the periodic planar representation). Our construction actually proceeds on certain closely related bipartite with all faces of degree 4 except hexagonal root-face. show these well-characterized unicellular maps. bijection, to recent one by Bonichon and Lévêque 4-connected triangulations, can be seen as cou...
Acute lung injury (ALI) is a syndrome with significant morbidity and mortality, but its genetic susceptibility is not clearly understood. In the present study, we characterized functional promoter single nucleotide polymorphisms (SNPs) in the phase II antioxidant gene NQO1 (NAD(P)H:quinone oxidoreductase1) to evaluate its role in susceptibility to ALI. Three previously uncharacterized SNPs in t...
Despite decades of research, acute respiratory distress syndrome (ARDS) remains an important clinical challenge due to an incomplete understanding of the pathophysiological mechanisms. No FDA-approved drug therapy currently exists for treatment of humans with ARDS. There is accumulating evidence in rodents and humans suggesting that extracellular histones are strong drivers of inflammation and ...
Acute lung injury (ALI) is an inflammation of the lungs with high incidence rate and mortality. Ferroptosis a new cell death, which has influence in body organs. Transient receptor potential vanillin-4 (TRPV4) channel key mediator Ca2+, its activation induces ferroptosis. The purpose study to investigate function TRPV4 on ferroptosis ALI mice induced by lipopolysaccharide (LPS). In vitro, regul...
BACKGROUND Ventilator practices in patients at risk for acute lung injury (ALI) and ARDS are unclear. We examined factors associated with choice of set tidal volumes (VT), and whether VT < 8 mL/kg predicted body weight (PBW) relates to the development of ALI/ARDS. METHODS We performed a secondary analysis of a multicenter cohort of adult subjects at risk of lung injury with and without ALI/AR...
Consider the set of those binary words with no non-empty factors of the form xxx R. Du, Mousavi, Schaeffer, and Shallit asked whether this set of words grows polynomially or exponentially with length. In this paper, we demonstrate the existence of upper and lower bounds on the number of such words of length n, where each of these bounds is asymptotically equivalent to a (different) function of ...
Fibrin impairs surfactant function in vitro, and inhibition of fibrinolysis by plasminogen activator inhibitor (PAI-1) is thought to promote fibrin accumulation in acute lung injury (ALI). This has led to speculation that impaired PAI-1 and fibrin accumulation should protect lung function in ALI. We tested this hypothesis by investigating ALI severity in fibrinogen-deficient (Fgn-/-) and PAI-1-...
Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by cardiolipin synthase (CLS1). Here, we show that S. aureus activates a ubiquitin E3 ligase component, Fbxo15, that is sufficient to mediate proteasomal ...
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