Peptides as a kind of important chiral scaffold are broadly identified for their obvious advantages, diverse structures and accessibility. Based on promiscuous aldo-keto-reductase enzymes, several mimetic peptides were designed which were synthesized and tested as multifunctional organocatalysts in direct asymmetric aldol reactions. The corresponding aldol products were produced with high yield...

Aad, G., Abbott, B., Abdallah, J., Abdel Khalek, S., Abdinov, O., Aben, R., Abi, B., Abolins, M., AbouZeid, O., Black, C., Cuthbert, C., Finelli, K., Jeng, G., Patel, N., Saavedra, A., Scarcella, M., Varvell, K., Watson, I., Yabsley, B., et al (2016). Centrality, rapidity, and transverse momentum dependence of isolated prompt photon production in lead-lead collisions at sNN =2.76 TeV measured w...

In this paper, a low-voltage low-dropout analog regulator (ALDO) based on native n-channel MOS transistor is proposed. Application of the with threshold voltage close to zero allows elimination charge pump in regulators using pass element common drain configuration. Such configuration simplification design and improved performance, supply voltages below 1 V, compared commonly used p-channel tra...

The M-1 cell line, derived from the mouse cortical collecting duct (CCD), is being used as a mammalian model of the CCD to study Na+ transport. The present studies aimed to further define the role of various hormones in affecting Na+ transport in M-1 cells grown in defined media. M-1 cells on permeable support, in serum-free media, developed amiloride-sensitive current 4-5 days after seeding. A...

The aldo-keto reductases metabolize a wide range of substrates and are potential drug targets. This protein superfamily includes aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases and dihydrodiol dehydrogenases. By combining multiple sequence alignments with known three-dimensional structures and the results of site-directed mutagenesis studies, we have developed a structure/...

Glucocorticoid (GR) and mineralocorticoid (MR) receptors are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Little is known about the function of GR and MR in avian species. Recently, the chicken homologue of the GR (cGR) gene was cloned, and its tissue-specific expression was characterized, whereas the full-length sequence of the chicken MR (cMR...

Although Cyclophosphamide and other oxazaphosphorine cytostatics are among the oldest and most widely used drugs in cancer chemotherapy, little is known about the cause of the high antitumor activity of this class of alkylating drugs compared to other alkylating cytostatics. In the present article a new scheme for the mechanism of action of oxazaphosphorine cytostatics based on the finding that...

Two non-canonical amino acids (ncAAs) with bio-orthogonal reactive groups, namely, p-azido-L-phenylalanine (p-AzF) and p-propargyloxy-L-phenylalanine (p-PaF), were genetically inserted into an aldo-keto reductase (AKR) alcohol dehydrogenase (ADH), respectively, at...