TThis paper investigates the effect that body weight and gender have on the transdermal transport of ethanol observed after the ingestion of an alcohol beverage. The approach is to use a computational model which combines a multi-compartment ethanol metabolism model with a transdermal transport model. Males have a larger proportion of alcohol soluble body mass when compared to females of the sa...

Epidemiological studies reveal a J-shaped association between alcohol consumption and arterial stiffness, with arterial stiffening lower among mild-to-moderate drinkers than heavy drinkers or nondrinkers. This study aimed to examine the effects of ingesting a small amount of beer, corresponding to the amount consumed per day by a mild drinker, on arterial stiffness. Eleven men (20-22 years) par...

Prolonged excessive ingestion or consumption of alcohol eventually results in hepatic insufficiency; induces the aggravation of viral hepatitis and/or fatty liver. The long term ingestion of alcohol not only induces a decline in the immune function but also promotes the production of inflammatory cytokines by Kupffer cells activated by enterobacterial endotoxins. Royal Jelly has numerous functi...

Alcohol consumption is one of the major causes of hepatic steatosis, fibrosis, cirrhosis, and superimposed hepatocellular carcinoma. Ethanol metabolism alters the NAD(+)/NADH ratio, thereby suppressing the activity of sirtuin family proteins, which may affect lipid metabolism in liver cells. However, it is not clear how long-term ingestion of ethanol eventually causes lipid accumulation in live...

Changes in cardiac metabolism in myocardial failure and after alcohol ingestion are discussed. The main effect of alcohol ingestion is loss of cardiac contractility. Since heart muscle does not contain alcohol dehydrogenase, its toxicity is probably the result of a direct toxic effect of ethanol and acetaldehyde on the myocardial cell, possibly involving various membrane systems. Alcohol inhibi...

Recent studies from our laboratory have shown that alcohol and burn injury impair intestinal barrier and immune functions. Although multiple factors can contribute to impaired intestinal barrier function, such an alteration could result from a decrease in intestinal blood flow (BF) and oxygen delivery (DO2). Therefore, in this study, we tested the hypothesis that alcohol ingestion before burn i...

INTRODUCTION The culture in many team sports involves consumption of large amounts of alcohol after training/competition. The effect of such a practice on recovery processes underlying protein turnover in human skeletal muscle are unknown. We determined the effect of alcohol intake on rates of myofibrillar protein synthesis (MPS) following strenuous exercise with carbohydrate (CHO) or protein i...

An adult dog were evaluated for treatment loss of consciousness, convulsions, and severe tremors after ingestion xylitol, a sugar alcohol used as sweetener in various products. Clinical findings noted tremors, while physio-pathological included moderately to severely elevated serum activities liver enzymes, hypoglycaemia hypophosphatemia. To correct hypoglycaemia, dextrose was administered intr...

AIMS Catecholamines (CA) inhibit leptin secretion. Alcohol appears to have a similar effect. The mechanism underlying the inhibitory effect of alcohol is unknown, but CA may play a role as mediators. This hypothesis has never been tested. We decided to do so in the present investigation. METHODS Seven healthy subjects participated in two experiments (A and B), performed in random order, 1 wee...

Since alcohol is a general central nervous system depressant, it affects the motor and cognitive performance. Alcohol abuse is a major cause of medical and social problems. Additionally, to determine cause of death in legal medicine centers, alcohol analysis is the most frequently performed test in forensic toxicology laboratories. Accurate interpretation of ethanol concentration at the time...