BACKGROUND Cancer chemotherapy is still hampered by clinical failures due to multi-drug resistance (MDR) of tumor cells. In the present study, we have investigated the cytotoxicity of 20 methanol extracts from 10 medicinal plants against the sensitive leukemia CCRF-CEM cells. The most cytotoxic extracts were then further tested on a panel of 8 human cancer cell lines, including various MDR phen...

In order to continue the research of natural compounds of interest such as pesticides and therapeutic molecules in endemic species of Albizia from Madagascar, potentials of Albizia odorata seed extract were assessed. A toxic saponin (saponoside), named Albodorine, was isolated by extraction with hot ethanol or distilled water followed by purification procedure comprising n-butanol partition, pr...

Bioassay-guided fractionation of a CH(2)Cl(2)-MeOH extract of the aerial parts of Albizia inundata resulted in the isolation of two new natural oleanane-type triterpene saponins {3-O-[α-L-arabinopyranosyl(1→6)]-2-acetamido-2-deoxy-β-D-glucopyranosyl oleanolic acid (1) and 3-O-[α-L-arabinopyranosyl(1→2)-α-L-arabinopyranosyl(1→6)]-2-acetamido-2-deoxy-β-D-glucopyranosyl acacic acid lactone (2)} al...

Phytochemical investigation of the methanolic extract of the roots of Albizzia lebbeck Benth. (Fabaceae) led to the isolation of one new fatty acid ester 2' αhydroxy octyl hexadecanoate (hydroxyoctyl palmitate) and two new phenolic acid glucosidic ester characterized as salicylic acid-2-O–β-D-glucofuranosyl-6'-octadec-9"-enoate (salicylic acid arabinosyl oleate) along with a fatty acid phytocon...

The effect in alcoholic extract of Bark of Albizzia lebbeck was studied for antifilarial activity using Setaria cervi (S. cervi) worm procured from the freshly slaughtered buffalo.We used the whole worm (w.w.) preparation and nerve muscle (n.m.) complex of Setaria cervi (S. cervi). The n.m. complex is made by stripping the cuticle of the worm. The effect was stimulant in nature in both the prep...