Amyotrophic lateral sclerosis has been linked to the gain of aberrant function of superoxide dismutase, Cu,Zn-SOD1 upon protein misfolding. The mechanism of SOD1 misfolding is thought to involve mutations leading to the loss of Zn, followed by protein unfolding and aggregation. We show that the removal of Zn from SOD1 may not lead to an immediate unfolding but immediately deactivates the enzyme...

Article history: Received 30 December 2010 Received in revised form 27 February 2011 Accepted 2 March 2011 Available online 6 April 2011 0026-2714/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.microrel.2011.03.019 ⇑ Corresponding author. Tel.: +1 607 777 3415. E-mail address: [email protected] (S. Park). This paper focuses on the characterization of the elasto-plastic properties of ...

OBJECTIVE To investigate fetal exposure to toxic metals [lead (Pb), cadmium (Cd)] and fetal levels of trace elements [zinc (Zn), copper (Cu), and iron (Fe)] in newborns from an industrial city. Relationships between meconium mineral contents and parental occupation and location of residence were also tested. METHOD The meconium mineral contents of 117 healthy newborn infants were measured by ...

Catalytic hydrotreating of algae bio-crude oil from hydrothermal liquefaction (HTL) Nannochloropsis sp. was performed. Different Ni-based catalysts, including Ni/γ-Al2O3, Ni-Cu/γ-Al2O3, Ni-Re/γ-Al2O3, and Ni-Cu-Re/γ-Al2O3, (10%Ni, 5%Cu, 2.5%Re) were used in upgrading the oil. Most catalytic systems could effectively eliminate S decrease N O contents, enhance more than 20% improvement higher hea...

Co-landfilling of incineration ash and cellulose might facilitate the alkaline degradation of cellulose. A major degradation product is isosaccharinic acid (ISA), a complexing agent for metals. The impact of ISA on the mobility of Pb, Zn, Cr, Cu and Cd from a municipal solid waste incineration dry scrubber residue was studied at laboratory using a reduced 2(5-1) factorial design. Factors invest...

This study reports 78 Rietveld quantitative phase analyses using Cu Kα1, Mo Kα1 and synchrotron radiations. Synchrotron powder diffraction has been used to validate the most challenging analyses. From the results for three series with increasing contents of an analyte (an inorganic crystalline phase, an organic crystalline phase and a glass), it is inferred that Rietveld analyses from high-ener...

The study discussed the synthesis of silica sol using the sol-gel method, doped with two different amounts of Cu nanoparticles. Cotton fabric samples were impregnated by the prepared sols and then dried and cured. To block hydroxyl groups, some samples were also treated with hexadecyltrimethoxysilane. The average particle size of colloidal silica nanoparticles were measured by the particle size...