PURPOSE Adolescent idiopathic scoliosis (AIS), the most common pediatric spinal deformity, is considered a complex genetic disease. Causing genes and pathogenesis of AIS are still unclear. This study was designed to identify differentially expressed long noncoding RNAs (lncRNAs) involving the pathogenesis of AIS. METHODS We first performed comprehensive screening of lncRNA and mRNA in AIS pat...

Acute ischemic stroke (AIS) is a common cause of morbidity and mortality worldwide. Thrombolytic therapy with tissue plasminogen activator, the only approved treatment for AIS, is received by less than 2% of patients. Moreover, there is a slight increase in hemorrhagic complications with thrombolysis. Therefore, there is a need for newer therapeutic modalities in AIS, which could be used in win...

Little is known about the specific contributions of aging to the neuron dysfunction and death in Alzheimer's disease (AD). AD is characterized by the pathological accumulation of abnormal tau (a microtubule-associated protein), and the mislocalization of tau from the axon to the somatodendritic compartment is thought to play an important role in disease pathogenesis. The axon initial segment (A...

In this paper we study the plausibility of navigation relevant AIS parameter based on time series analysis of HELCOM AIS data, obtained during September 2011. Previous analysis [1] of AIS data sets were mainly based on studies of not known or not existent (default) values in the AIS messages. The results of these studies have shown that especially true heading (THDG) and rate of turn (ROT) para...

The third-generation aromatase inhibitors (AIs), letrozole, anastrozole and exemestane, are becoming the first choice endocrine drugs for post-menopausal women with breast cancer, since they present greater efficacy when compared with tamoxifen in both adjuvant and metastatic setting. In particular, several large and well designed trials have suggested an important role for AIs in the adjuvant ...

BACKGROUND The incidence of pulmonary failure in trauma patients is considered to be influenced by several factors such as liver injury. We intended to assess the association of various potential predictors of pulmonary failure following thoracic trauma and liver injury. METHODS Records of 12,585 trauma patients documented in the TraumaRegister DGU® of the German Trauma Society were analyzed ...

BACKGROUND Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains controversial, genetic factors are thought to play key roles in the development of AIS. In a recent genome-wide association study, a polymorphism in the interleukin-17 receptor C (IL-17RC) gene was reported to be associated with the susceptibility to AIS, implicating IL-17RC as a novel predisposing gene for AI...

Interleukin-33 (IL-33), a newly recognized IL-1 family member, is expressed in various tissues and cells, and involved in pathogenesis of many human diseases. For example, IL-33 plays a protective role in cardiovascular diseases. However, the role of IL-33 in acute ischemic stroke (AIS) remains unclear. This study aims to investigate whether IL-33 level in AIS patient serum can be used as a pot...

1.1. Articole publicate in reviste cotate ISI. [1] A.L. Agore, G. Militaru, Unified products for Leibniz algebras. Applications, 25 pagini, Linear Algebra and its Applications, DOI: 10.1016/j.laa.2013.07.021. (IF 2012: 0,968; AIS 2012: 0,582) [2] A.L. Agore, G. Militaru, Extending structures for Lie algebras, 24 pagini, Monatshefte für Mathematik, DOI: 10.1007/s00605-013-0537-7. (IF 2012: 0,698...