We thank Jigar Patel and colleagues for their comments. The mean duration of symptoms at enrolment was 5·77 days (SD 3·49) in the azithromycin group 6·27 (3·55) standard care group. 19 (13%) 147 participants 21 (14%) 148 had more than 10 randomisation. Most COVID-19-related deaths occur due to sudden, late respiratory decompensation, peaking day 14 after symptom onset.1Ruan Q Yang K Wang W Jian...

In this open ing prov o ca tion, Freud and Heidegger make as ser tions which stand, prima fa cie, in ex treme op po si tion to one an other—with Derrida sit u ated, not sur pris ingly, some where in-be tween. But be tween what? What is the philo soph i cal sig nif i cance of the cog ni tive re la tion one stands in with re spect to one’s own death? Be tween (1) Heidegger’s as ser tion that hold...

The populations in greatest need of iron supplementation are also those at greatest risk of malaria: pregnant women and young children. Iron supplementation has been shown to increase malaria risk in these groups in numerous studies, although this effect is likely diminished by factors such as host immunity, host iron status, and effective malaria surveillance and control. Conversely, the risk ...

lbe card game Elcllsis [1.51 poscs an induct:on problem in which no single model-bascd gcncralization Sp.1CC capturcs all of the desircd gcncf:lliz.1tions of the input data. A progr:lr:l has becn dcvcloped which solves this problem by se.1(":hing scveral ditTerem genNali7..1tion spaces for pl.111Siblc Elcusis rules. Multiple generalization spaces require multiple data transformation mcthods "fo...

Diffusetes from seedlings and root exudates from 6-week-old plants of a monoecious line of cucumber, Cucumis sativus L., contained considerably higher levels of gibberellin.(GA-)like substances than did those from plants of an isogenic gynoecious line. Most of the GA4ike activity was found in a chromatogram region ty.pical of GA1 and GA3; some activity, particularly in root exudates, appeared a...

Fruit yield, earliness, and quality have low to moderate heritability, but are traits of major importance in cucumber (Cucumis sativus L.). The objective of this study was to determine the changes made in those traits using recurrent selection in three slicing cucumber populations (NCMBS, NCES1, and NCBA1). During population improvement, one or two replications of 200 to 335 half-sib families w...

Exposure of U937 cells to an otherwise nontoxic concentration of peroxynitrite promotes a rapid necrotic response in the presence of pharmacological inhibitors of phospholipase A2. A 12fold higher concentration of the oxidant, in the absence of additional treatments, caused remarkably greater DNA singlestrand breakage, delayed formation of H2O2, and depletion of reduced glutathione but an ident...

Dietary lipids and fat-soluble micronutrients are solubilized in mixed micelles and absorbed in the small intestine. Based on an assumption that cholesterol and other fat-soluble molecules share a number of transport mechanisms and the fact that Niemann-Pick C1-like 1 (NPC1L1) is critical for intestinal cholesterol absorption, we hypothesized that some fat-soluble molecules may be transported b...

Free AccessSupporting Academic Freedom and Living Societal ResponsibilityThe Role of Authors, Reviewers, Editors in the Publication Process at EJPADragos Iliescu, Samuel Greiff, René Proyer, Matthias Ziegler, Mark Allen, Laurence Claes, Marjolein Fokkema, Penelope Hasking, Annemarie Hiemstra, Marlies Maes, Marcus Mund, Chris Nye, Ronny Scherer, Eunike Wetzel, Pia ZeinounDragos Iliescu Faculty P...

Water stress applied to the plant shoot through enhanced evaporative demands reduced cytokinin activity in extracts of xylem exudate and leaves. This reduction resembled the changes in cytokinin activity caused by water stress applied to the root. Cytokinin activity in detached wilting leaves decreased rapidly. Recovery took place after several hours in a humid chamber. Experiments with "4C-kin...