This is an overview of the phenomenon of population ageing and ageing trends in Jamaica. It documents landmark policy achievements and responses to population ageing and analyses related social, economic and health implications, as well as, the challenges and opportunities of ageing. The interdigitations of ageing issues and public health is manifest from the early historical milestones in agei...

BACKGROUND Very few over-the-counter cosmetic 'anti-ageing' products have been subjected to a rigorous double-blind, vehicle-controlled trial of efficacy. Previously we have shown that application of a cosmetic 'anti-ageing' product to photoaged skin under occlusion for 12 days can stimulate the deposition of fibrillin-1. This observation infers potential to repair and perhaps clinically improv...

This work investigates the effect of long-term environmental exposure on performance composite-to-metal bonded joints. Specimens are manufactured using a carbon-fiber reinforced polymer (CFRP) co-bonded to steel member with epoxy adhesive and aged in salt spray chamber. The mixed-mode fracture behavior non-aged specimens is assessed bending (MMB) test apparatus. energy calculated finite element...

AgeFactDB (http://agefactdb.jenage.de) is a database aimed at the collection and integration of ageing phenotype data including lifespan information. Ageing factors are considered to be genes, chemical compounds or other factors such as dietary restriction, whose action results in a changed lifespan or another ageing phenotype. Any information related to the effects of ageing factors is called ...

Managing a nuclear power plant (NPP) calls for evaluation and trading off the conflicting objectives of safe operation and economic burden. The reduction of NPP risk is strongly correlated to the reduction of NPP safety systems unavailability. The application of the probabilistic safety assessment in order to reduce safety systems unavailability is one of the prime goals in the nuclear safety a...

Most mechanisms of ageing are believed to be more or less associated with inflammation. With age, a unique form chronic inflammation develops which is termed as inflamm-ageing. The this process still not fully clear due the lack reliable assessment criteria. Immune system among those involved in accelerating age-related changes body. It also directly participates In its pathogenesis, reaction m...

We sought to use splice-switching antisense oligonucleotides to produce a model of accelerated ageing by enhancing expression of progerin, translated from a mis-spliced lamin A gene (LMNA) transcript in human myogenic cells. The progerin transcript (LMNA Δ150) lacks the last 150 bases of exon 11, and is translated into a truncated protein associated with the severe premature ageing disease, Hut...