DNA damage has been implicated in ageing, but direct evidence for a causal relationship is lacking, owing to the difficulty of inducing defined DNA lesions in cells and tissues without simultaneously damaging other biomolecules and cellular structures. Here we directly test whether highly toxic DNA double-strand breaks (DSBs) alone can drive an ageing phenotype using an adenovirus-based system ...

Pruritus occurs frequently in the elderly population, but it has not been fully defined and its precise prevalence is unknown. Putative causes of pruritus are numerous and patients' quality of life can be greatly reduced. In the absence of any specific cause, a diagnosis of senile pruritus is proposed, suggesting that itch is secondary to ageing. However, the relationship of pruritus with skin ...

introduction: elder abuse may increase the vulnerability of ageing people to disease and decrease their general health status, so addressing the issue is essential for promoting elderly quality of life. the study aimed to examine the relation between abuse experience and general health among elderly people in yazd city- iran. methods: the cross-sectional study carried out on 250 community-dwell...

PPARs play a pivotal role in regulating lipid and glucose homeostasis and are involved in diverse biological activities in skin. Pomegranate flower (PGF, an antidiabetic therapy in Unani and Ayurvedic medicines) has been previously demonstrated to activate both PPARalpha/gamma. Here, we found that treatment of mice with the diet containing PGF powder over 55 weeks attenuated ageing-induced abno...

All cells possess surveillance and homeostatic mechanisms to adjust protein biogenesis to the demands of growth, differentiation, ageing and environmental stress. However, under certain circumstances, these mechanisms fail to adequately respond to proteotoxic imbalances and result in the accumulation of misfolded proteins. In humans, this can lead to neurodegeneration and other protein conforma...

Black carbon (BC) particles in the atmosphere have important impacts on climate. The amount of BC in the atmosphere must be carefully quantified to allow evaluation of the climate effects of this type of aerosol. In this study, we present the treatment of BC aerosol in the developmental version of the 4th generation Canadian Centre for Climate modelling and analysis (CCCma) atmospheric general ...

District heating networks are used worldwide, especially in Scandinavian countries and also in many other countries, e.g. Germany, Russia, United States, South Korea and China. From an environmental point of view, district heating networks are a good alternative to more traditional building heating systems. In 1970th, the third generation of district heating systems was established on the marke...

cacl2 treatment followed by heat shock is the most common method for artificial transformation. here, the cells were transformed using cacl2 treatment either with heat shock (standard protocol) or without heat shock (lab protocol) to comprehend the difference in transformation efficiency. the bl21 strain of escherichia coli (e. coli) was being susceptible using cacl2 treatment. some cells were ...

The microstructural evolution during low temperature ageing of two commercial purity alloys (Al1.2Cu-1.2Mg-0.2Mn and Al-1.9Cu-1.6Mg-0.2Mn at.%) was investigated. The initial stage of hardening in these alloys is very rapid, with the alloys nearly doubling in hardness during 20 h ageing at room temperature. The microstructural evolution during this stage of hardening was investigated using diffe...

This paper deals with the temperature-dependent modelling of iron losses in context magnetic ageing electricals steel used high power electrical machines. First, two sheet grades were heat treated at three temperatures order to study effect evolution as a function temperature. Results show significant increase for both grades. Then, considering link between macroscopic properties (effect) and m...