Dong, Lily Q., and Feng Liu. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. Am J Physiol Endocrinol Metab 289: E187–E196, 2005; doi:10.1152/ajpendo.00011.2005.—Activation of members of the protein kinase AGC (cAMP dependent, cGMP dependent, and protein kinase C) family is regulated primarily by phosphorylation at two sites: a conserved threonine residue in the...

PURPOSE Chemotherapy plus trastuzumab is standard of care for HER2-positive advanced gastric cancer (AGC). However, not all patients with HER2-positive AGC seem to benefit from trastuzumab. We evaluated the association between treatment outcomes with trastuzumab and HER2 status in patients with HER2-positive AGC. EXPERIMENTAL DESIGN We enrolled 126 patients with HER2-positive AGC treated with...

The AGC protein kinase family (cAMP-dependent protein kinases A, cGMP-dependent protein kinases G, and phospholipid-dependent protein kinases C) have important roles regulating growth and development in animals and fungi. They are activated via lipid second messengers by 3-phosphoinositide-dependent protein kinase coupling lipid signals to phosphorylation of the AGC kinases. These phosphorylate...

There is an increasing interest in monolithic integration for wireless transceivers. This integration can be made possible with the advantages of direct conversion techniques. However, DC offset and flicker noise become critical to the system. In this paper, we propose a wide tuning range and high gain AGC with an effective automatic DC offset cancellation. The proposed AGC and transceiver arch...

No standard treatment has been accepted widely for the first-/second-line therapy for advanced gastric cancer (AGC). The current study aimed to determine a preferred strategy between FOLFIRI (fluorouracil, leucovorin, and irinotecan) and ECX (epirubicin, cisplatin,and capecitabine) for AGC from the cost-effectiveness perspective. According to a French intergroup study, two groups (ECX arm and F...

The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis of human cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes and their inhibitor (TIMP-2) constitute promising targets in the development of anticancer therapies. In order to investigate the correlation between expressions of TIMP-2, MMPs and clinical o...

The variable (V) regions of immunoglobulin heavy and light chains undergo high rates of somatic mutation during the immune response. Although point mutations accumulate throughout the V regions and their immediate flanking sequences, analysis of large numbers of mutations that have arisen in vivo reveal that the triplet AGC appears to be most susceptible to mutation. We have stably transfected ...

The aboveground carbon (AGC) storage of open Eucalyptus forests is unknown yet they are estimated to account for almost 25% of all Australian forests and about 60% of forests in Victoria. In this study we provide the best possible estimates of total AGC including tree biomass derived from destructive biomass sampling across 23 study plots established in open Eucalyptus forests in Victoria. The ...

Juan Pablo Alegre et al. 729 Wireless communication systems, such as WLAN or Bluetooth receivers, employ preamble data to estimate the channel characteristics, introducing stringent settling-time constraints. This makes the use of traditional closed-loop feedback automatic gain control (AGC) circuits impractical for these applications. In this paper, a compact feedforward AGC circuit is propose...

This paper demonstrates the use of particle swarm optmization for optimizing the parameters of automatic generation control systems (AGC). An integral controller and a proportional-plus-integral controller are considered. A two-area reheat thermal system is considered to exemplify the optimum parameter search. The optimal AGC parameters search is formulated as an optimization problem with a sta...