Glycation of proteins forms fructosamines and advanced glycation endproducts. Glycation adducts may be risk markers and risk factors of disease development. We measured the concentrations of the early glycation adduct fructosyl-lysine and 12 advanced glycation endproducts by liquid chromatography with tandem mass spectrometric detection. Underivatized analytes were detected free in physiologica...

Nonenzymatic glycation of low density lipoprotein (LDL) is a reaction of glucose and other reducing sugars with apolipoprotein B100 (apo-B100) lysine residues. In diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. The objective of this study was to investigate in vitro effects of ?-tocopherol, ascorbic acid and lycopene on LDL glycatio...

BACKGROUND Many of the complications encountered during diabetes can be linked to the non-enzymatic glycation of proteins, including human serum albumin (HSA). However, there is little information regarding how the glycation pattern of HSA changes as the total extent of glycation is varied. The goal of this study was to identify and conduct a semi-quantitative comparison of the glycation produc...

PURPOSE The aim of this study was to investigate the topical efficacy of a new purified extract from Madagascar, Gotu Kola (Centella asiatica [L.] Urban), both on human explants and on human volunteers, in relation to skin wrinkling and skin protection against ultraviolet light exposure. The extract, with a peculiar content of biologically active molecules, was investigated as a novel anti-infl...

Submit Manuscript | http://medcraveonline.com Abbreviations: AGE: Advanced Glycation End-Product; Angii: Angiotensin II; CAD: Coronary Artery Disease; Dia-1: Diaphanous-1; DN: Dominant-Negative; Hba1c: Glycated Haemoglobin; HMGB1: High-Mobility Group Box-1; LTA: Lymphotoxin Α; NF-Κb: Nuclear Factor Κb; NMD: Nonsense-Mediated Mrna-Decay; PBX2: Pre-BCell Leukaemia Homeobox 5; RAGE: Receptor for A...

Nonenzymatic glycation of low density lipoprotein (LDL) is a reaction of glucose and other reducing sugars with apolipoprotein B100 (apo-B100) lysine residues. In diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. The objective of this study was to investigate in vitro effects of ?-tocopherol, ascorbic acid and lycopene on LDL glycatio...

The metabolism of the glycation product fructose-epsilon-lysine in Escherichia coli involves its ATP-dependent phosphorylation by a specific kinase (FrlD), followed by the conversion of fructoselysine 6-phosphate into glucose 6-phosphate and lysine by fructoselysine-6-phosphate deglycase (FrlB), which is distantly related to the isomerase domain of glucosamine-6-phosphate synthase. As shown in ...

background: glycation of proteins is a non-enzymatic spontaneous process that occurs in diabetes mellitus and aging, altering the structure and function of proteins. igg undergoes glycation leading to changes in its reactivity to antigen and fixation of complement.   objective: this study aimed at revealing the effect of glycation on the interaction of igg with anti-igg using electroimmunoassay...

MARKET RESPONSE MEASUREMENT USING THE MULTINOMIAL, MULTIATTRIBUTE LOGIT CHOICE MODEL by Peter Manning Guadagni Submitted to the Alfred P. Sloan School of Management on May 15, 1980, in partial fulfillment of the requirements for the degree of Master of Science. Universal Product Code (UPC) scanning is the key to a new marketing data source. Unfortunately, most existing marketing models do not h...