نتایج جستجو برای: adult hemoglobin
تعداد نتایج: 356203 فیلتر نتایج به سال:
During development, human beta-globin locus regulation undergoes two critical switches, the embryonic-to-fetal and fetal-to-adult hemoglobin switches. To define the role of the fetal (A)gamma-globin promoter in switching, human beta-globin-YAC transgenic mice were produced with the (A)gamma-globin promoter replaced by the erythroid porphobilinogen deaminase (PBGD) promoter (PBGD(A)gamma-YAC). A...
Induction of fetal hemoglobin (HbF) production in adult erythrocytes can reduce the severity of sickle cell disease and β-thalassemia. Transcription of β-globin genes is regulated by the distant locus control region (LCR), which is brought into direct gene contact by the LDB1/GATA-1/TAL1/LMO2-containing complex. Inhibition of G9a H3K9 methyltransferase by the chemical compound UNC0638 activates...
OBJECTIVE To determine the point prevalence of urine bilirubin, urine hemoglobin and urobilinogen in blunt trauma patients, and to evaluate its utility as a screening tool for intra-abdominal injury. METHODS Data analysis of 986 consecutive trauma patients of which 698 were adult blunt trauma patients. Five-hundred sixteen subjects had a urinalysis and a CT scan of the abdomen/pelvis or explo...
Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of lentiviral vectors to increase hemoglobin synthesis might vary in different patients.We generated lentiviral vectors carrying the human β-globin gene wi...
Hemoglobin prepared from red blood cells of adult Japanese Monkeys (Macaca fuscata fuscata) was removed heme so that globin was obtained. The • @ globin • @ was • @ separated • @into • @ ƒ¿ • @ and ƒÀ polypeptide • @ chains • @ by • @ countercurrent distribution with the system of sec-butanol containing trichroloacetic acid, propionic • @ acid, • @and • @water. • @ The,ƒÀ • @ polypeptide • @ ch...
OBJECTIVE To investigate the effect of type 1 diabetes on growth and adult height. STUDY DESIGN Data from 22 651 children (10 494 females) with type 1 diabetes documented at onset of the disease from specialized centers in Germany and Austria were analyzed. Patients of non-German and non-Austrian origin and patients with celiac disease were excluded from the analysis. Near-adult height data w...
OBJECTIVE To determine whether phlebotomy contributes to changes in hemoglobin and hematocrit levels in hospitalized general internal medicine patients. DESIGN Retrospective cohort study. SETTING General internal medicine inpatient service at a tertiary care hospital. PARTICIPANTS All adult patients discharged from the Toronto General Hospital's internal medicine service between January 1...
introduction: musculoskeletal growth is variable during adolescent period and reaches its maximum by 18 years, whereas hemopoietic parameters reach adult values by 15 years. after adolescence period, the blood parameters may vary with nutrition and built of the individual. the purpose of this study was to find out any correlation between anthropometric and hematological parameters after the ado...
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