CONTEXT Primary pigmented nodular adrenocortical disease (PPNAD) can lead to steroid hormone overproduction. Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop. OBJECTIVE Investigation of regulation of steroidogenesis in a case of PPNAD with virilization. ...

BACKGROUND Primary aldosteronism can be caused by adrenocortical adenoma and is usually associated with left ventricular hypertrophy. Biventricular cardiac hypertrophy and heart failure in the presence of a pre-existing atrial septal defect (ASD) are a rare association of primary aldosteronism. CASE REPORT A 33-year-old woman with resistant hypertension and refractory hypokalemia presented with...

Abstract Introduction Racemic ketoconazole (RK) is a steroidogenesis inhibitor used for treatment of Cushing’s syndrome. Levoketoconazole (COR-003), the pure 2S,4R enantiomer, potentially more potent and safe compared to RK. We in vitro effects levoketoconazole RK on adrenocortical pituitary adenoma cells. Materials methods HAC15 cells 15 primary human neoplastic cultures (+/− ACTH), murine (At...

Adrenal disease can refer to changes to the adrenal cortex and/or to the adrenal medulla. The most common form of adrenal medulla pathology is a pheochromocytoma. These rare tumors are usually much larger than tumors of the adrenal cortex and can remain unnoticed for a long time. Although cases have been reported where pheochromocytomas have been diagnosed based on histologic characteristics of...

CONTEXT Adrenocortical virilizing tumors are rare in the pediatric age group. Laparoscopic surgery is the gold standard method for treatment of adrenal functional tumors under 6 cm in size, in adults. There has been very little use of laparoscopy in children and there is no report of its application in the treatment of adrenal carcinoma in childhood. DESIGN Case report. CASE REPORT We perfo...

Adrenal incidentaloma (AI) is a term applied to an accidentally discovered adrenal mass on imaging performed for reasons unrelated to adrenal pathology. The widespread application of abdominal imaging procedure has resulted in an increased frequency of clinically silent adrenal masses. Although most AIs are nonfunctioning benign adenomas, a multidisciplinary approach with biochemical and radiol...

nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. no hypertension and cushingoid features were seen. serum alpha...