The effects of large doses of adrenocorticotropic hormone (ACTH) and of growth hormone on physiologic parameters and on the metabolism of N-hydroxy-JV^-fluorenylacetamide (N-OH-FAA) were investigated in Fischer male rats. ACTH, 96 or 80 units, and growth hormone, 12 or 10 mg, were injected s.c. daily for 10 consecutive days into animals prefed either control diet or the N-OH-FAA-containing diet...

INTRODUCTION The vestibular acute stress induces reversible alert-like reactions that involve the sympathetic adrenal-medullar system and hypothalamic-pituitary-adrenal axis responses. The present study aimed to evaluate salivary α-amylase and salivary cortisol production in relation with cardiovascular reactivity induced by acute stress in healthy subjects. MATERIAL AND METHODS Forty-eight y...

1 The pathophysiological definition of heart failure states that " cardiac failure is an inability of the heart to deliver blood (and therefore oxygen) at a rate commensurate with the requirements of the metabolising tissues at rest or during light exercise. This leads to characteristic systemic pathophysiological responses (neural, hormonal, renal and others), symptoms and signs.'' However, th...

Two patients witlh congestive cardiac failure were pllaced on a metabolic balance regimen ancl supplemental sodium chloride was administered. Weight changes in these patients could lbe closely correlated with the amount of sodium retention and .lpl)eared to be initially independent of bra-chial venous pressure thus supporting the concept that edemna in congestive failure results from prinmary. ...

ABSTRACT.: A potential role of the sympathetic nervous system in progression of renal failure has received little attention. This study examined whether nonhypotensive doses of moxonidine, an agent that reduces sympathetic activity, affects glomerulosclerosis, urine albumin excretion, and indices of renal handling of norepinephrine (NE) in subtotally nephrectomized (SNX) rats. Sprague Dawley ra...

It has recently been reported by Torii(1951)of this laboratory that the injection of alloxan to the rat was followed by a prompt and definite fall of the adrenal cholesterol content, especially ester cholesterol, but the levels of cholesterol in other tissues were nearly unchanged. These facts suggest strongly that there may exist an intimate relation between the initial hyperglycemia in the al...

1. Introduction induced calcium release from the sarcoplasmic reticulum, whereas the sustained inotropic effect during the sub-The force and frequency of myocardial contraction are sequent beats results from both increased influx and physiologically regulated by neurotransmitters and hor-increased mobilization of internal calcium resulting from mones. Norepinephrine released by the sympathetic ...

As stated in the introduction by R. A. Peters, the purpose of this issue of the British Medical Bulletin "is to present a cross section of the research now in progress in this field of membranes." Although the coverage of the field is by no means complete, this purpose is achieved reasonably well in a series of short and concise reviews by investigators who are actively working on the problems ...

By WILLIAM H. BEST, M.I)., AND MAX SAMTER, M.I). R ECENT interest in changing levels of circulating eosinophils as an index of I 1-oxysteroid output from the ad,’enal cortex demands a critical evaluation of the accuracy of individual counts, of the \‘alidit.y of comparing suecessive counts, and of physiologic variations in eosinophil level. The older literature is replete with investigations of...