Enhanced sympathetic signaling, often associated with obesity and chronic stress, is increasingly acknowledged as a contributor to cancer aggressiveness. In prostate cancer, intact sympathetic nerves are critical for tumor formation, and sympathectomy induces apoptosis and blocks tumor growth. Perineural invasion, involving enrichment of intra-prostatic nerves, is frequently observed in prostat...

In this study, allele and genotype frequencies of the ADRB1 Arg389Gly (rs1801253), ADRB2 Gly16Arg (rs1042713) and Gln27Glu (rs1042714), and ADRB3 Trp64Arg (rs4994) variations were compared in the following three groups of Spanish (Caucasian) men: (1) world-class endurance athletes (E; runners and cyclists, n=100), (2) elite power athletes (P; sprinters, jumpers and throwers, n=53) and (3) non-a...

Background. The study of the effect drugs at molecular genetic level in recurrent course bronchial obstruction (RBО) children improved understanding pathogenesis disease and made it possible to better characterize reliability use therapy. aim was assess clinical significance polymorphism Arg16Gly loci ADRB2 gene with a therapeutic response β2-agonists RBО Uzbek ethnicity. Materials methods. Tes...