Most of the present interest in the muscle protein actin stems directly from the fact, demonstrated by Straub and Feuer (2), that G-a&in binds adenosine triphosphate, and that concomitantly with the polymerization of G-actin, the bound adenosine triphosphate is converted to bound adenosine diphosphate (2). The association between protein and nucleotide differs depending on the state of polymeri...

Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra, showed both a central analgesic effect and a hyperalgesic effect in mice tests. In order to explore mechanisms, a hypothesis is put forward that cobra neurotoxin takes effect through adenosine receptor pathway. The central effects of cobra neurotoxin were evaluated using the hot plate test (a model of acute pai...

Previous studies have reported that the numbers of beta- and alpha-adrenergic receptors increase in ischemic myocardium. In vivo studies have raised questions regarding the mechanisms involved in the adrenergic receptor alterations and the consequences of these alterations. The purpose of this study was to evaluate potential relationships among beta-adrenergic receptor changes, high energy phos...

Particulate preparations obtained from a number of tissues, including liver, kidney, and muscle inactivated renal Dfructose 1,6-diphosphatase when they were incubated with the enzyme in the presence of adenosine triphosphate, magnesium ion, and cysteine. Purified swine kidney Dfructose 1,6diphosphatase and rat kidney uridine diphosphate-D-glucose-glycogen glucosyltransferase were inactivated by...

Hypoxia is common to several inflammatory diseases, where multiple cell types release adenine-nucleotides (particularly adenosine triphosphate/adenosine diphosphate). Adenosine triphosphate/adenosine diphosphate is metabolized to adenosine through a 2-step enzymatic reaction initiated by CD39 (ectonucleoside-triphosphate-diphosphohydrolase-1). Thus, extracellular adenosine becomes available to ...