biliary papillomatosis is a disorder characterized by numerous adenomatous polyps of variable distribution and extent in intrahepatic bile ducts. it should be considered as a premalignant condition because a high proportion of the lesions undergo malignant transformation. in this report, we present a patient with abdominal pain and jaundice. according to his presenting signs and symptoms, ercp ...

Background and aims  Probe-based confocal laser endomicroscopy (pCLE) is used to differentiate between neoplastic and non-neoplastic colorectal polyps during colonoscopy. We aimed to assess the accuracy of two endoscopists starting to use real-time pCLE for differentiation of colorectal polyps and to determine the negative predictive value (NPV) for neoplasia in polyps ≤ 5 mm. Methods  Patien...

Blood and lymphatic vessel proliferation is essential for tumor growth and progression. Most colorectal carcinomas develop from adenomas (adenoma-carcinoma sequence) in a process due to accumulation of molecular genetic alterations. About 5% of adenomatous polyps are expected to become malignant, but data on the differential angiogenic patterns of these lesions in patients with and without conc...

Sialosyl-Tn antigen and its immediate precursor, Tn antigen, are carbohydrate structures associated with the earliest steps of mucin O-linked glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of colorectal cancer. One hundred and three colorectal polyps (79 adenomatous; 24 hyperplastic) were examined for expression of Tn antigen using vicia vill...

Germ-line mutations in the APC gene cause adenomatous polyposis coli (APC), a syndrome in which patients develop hundreds to thousands of precancerous adenomatous colorectal polyps. We described previously an attenuated form of APC (AAPC) resulting from very 5' mutations in APC in which affected patients exhibit fewer colorectal polyps and a later age of onset of colorectal cancer. However, bec...

BACKGROUND Familial adenomatous polyposis (FAP) is a rare, autosomal dominant disease clinically characterized by the early onset of many adenomatous polyps throughout the colon, which turn into colon cancer, if left untreated. In FAP patients, polyps can also occur in the upper gastrointestinal (GI) tract, especially in the duodenum. Adenomas beyond duodenum are rare and mostly located in the ...

PURPOSE: The performance characteristics of CT virtual colonoscopy (VC) for detection of colorectal neoplasia have not been established in an average-risk screening population. We conducted a prospective multicenter VC screening trial using optical colonoscopy (OC) as the reference standard. METHODS: 1233 asymptomatic adults (mean age, 57.8 years; 728 men, 505 women) underwent VC examination fo...

INTRODUCTION Gastrointestinal lipomas, though rare are the second most common benign tumors of the colon after adenomatous polyps. The diagnosis is difficult and is often mistaken for adenomatous polyp or cancer (1). Management of incidentally detected asymptomatic large colon lipomas has not been well studied. To our knowledge, this is the first case report of asymptomatic colon lipoma that wa...

BACKGROUND Distal diminutive colorectal polyps are common and accurate endoscopic prediction of hyperplastic or adenomatous polyp histology could reduce procedural time, costs and potential risks associated with the resection. Within this study we assessed whether digital chromoendoscopy can accurately predict the histology of distal diminutive colorectal polyps according to the ASGE PIVI state...

AIM The aim of this study was to report the anatomical location and histologic type of colorectal polyps in a large series of Iranian patients that attended for colonoscopy. BACKGROUND Polyps that develop through the adenoma-carcinoma pathway are considered neoplastic and may eventually progress to invasive carcinomas. In addition polyps can develop with no neoplastic potential. These neoplas...