نتایج جستجو برای: adeno associated virus
تعداد نتایج: 1852842 فیلتر نتایج به سال:
γ-Sarcoglycanopathy or limb girdle muscular dystrophy type 2C is an untreatable disease caused by autosomal recessively inherited mutations of the γ-sarcoglycan gene. Nine non-ambulatory patients (two males, seven females, mean age 27 years; range 16-38 years) with del525T homozygous mutation of the γ-sarcoglycan gene and no γ-sarcoglycan immunostaining on muscle biopsy were divided into three ...
Abbreviations: Adeno-associated virus, (AAV); bacilli Calmette-Guerin, (BCG); base pairs, (bp); cottontail rabbit papilloma virus, (CRPV); E6-associated protein, (E6-AP); epidermal growth factor receptor, (EGFR); histone deacetylases, (HDAC); human papillomavirus, (HPV); inverted terminal repeats, (ITRs); listerolysin O, (LLO); of lysosome-associated membrane protein, (LAMP); open reading frame...
The use of vectors based on the small parvovirus adeno-associated virus has gained significant momentum during the past decade. Their high efficiency of transduction of postmitotic tissues in vivo, such as heart, brain, and retina, renders these vectors extremely attractive for several gene therapy applications affecting these organs. Besides functional correction of different monogenic disease...
Adenoviruses (Ad) have a long history as DNA-transfer vehicles in various medical applications including vivo gene therapy [1]. In this context, the favorable safety profile of Ad has been considered major benefit, since lack integration into host cell genome eliminates potential risks associated with insertional mutagenesis. This is combined comparatively high packaging capacity for foreign DN...
The three primary capsid proteins (A, B, and C) of adeno-associated viruses have been shown previously to contain overlapping amino acid sequences (R. McPherson and J. Rose, J. Virol. 46:523-529, 1983). In the present study we demonstrate definitively that these proteins are encoded in the right half of the adeno-associated virus 2 genome, and one or both of the smallest adeno-associated RNA sp...
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