Sustained exposure to various psychological stressors can exacerbate neuropsychiatric disorders, including drug addiction. Addiction is a chronic brain disease in which individuals cannot control their need for drugs, despite negative health and social consequences. The brains of addicted individuals are altered and respond very differently to stress than those of individuals who are not addict...

To suggest that the discovery of targetable driver mutations in many patients with advanced adenocarcinoma of the lung has completely transformed the work-up and therapeutic options for this disease would not be hyperbole. Although not curative, small-molecule tyrosine kinase inhibitors directed at oncogene-addicted tumors have led to significantly improved response rates compared with cytotoxi...

Consumption of psychoactive substances has two major effects: intoxication and addiction. These effects are related, re s p e c t i v e l y, to the psycho-pharmacological and economic-compulsive models of the connection between drugs and crime.5 The first model associates drug use and intoxication with a decrease in cognitive functions and a lack of self-control, leading to aggressive impulses,...

The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate transformation. Emerging evidence suggests that Tax is not needed to maintain the transformed ATL phenotype. Recent studies have shown that HTLV-1 transformed cells show deregulated expression of cellular microRNAs ...

Effectiveness of Multi-Dimensional Spiritual-Religious Psychotherapy on Mental Distress and Resiliency Addicted Women under Remedy

objective: opioid consumption has been widely increasing across the globe; however, it can cause adverse effects on the body. morphine, an opioid, can reduce sex hormones and fertility. withania somnifera (ws) is a traditional herb used to improve sexual activities. this study strives to investigate the effect of ws on sex hormones and gonadotropins in addicted male rats. materials and methods:...

objective(s):to determine the effect of acetylcholine (ach), pilocarpine, and atropine on pain evoked responses of pain excited neurons (pen) and pain inhibited neurons (pin) in hippocampal ca3 region of morphine addicted rats. materials and methods:female wistar rats, weighing between 230-260 g were used in this study. morphine addicted rats were generated by subcutaneous injection of increasi...

abstract background and objective: nas is a combination of signs and symptoms that due to physical and mental dependency, develops in neonates born from drug addicted mothers. the onset of nas varies in accordance with the type, amount, frequency and duration of substance used. because of diverse and unclear pattern of substance abuse in iranian addicted pregnant mothers in comparison with west...