Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk fac...

I Decary F, Fermer P, Giaredoni L, et al. An investigation of nonhaemolvtic transfusion reactions. Vox Sang 1984;46:277-85. 2 Moore SB, Taswell HF, Pineda AA, Sonnenberg CL. Delayed hemolytic transfusion reactions. Am7 Clin Pathol 1980;74:94-7. 3 Laskv LC, Rose RR, Poleskv HF. Incidence of antibody formation and positive direct antiglobulin tests in a muiltitransfuscd hemodialysis population. T...

OBJECTIVE Transfusion-related acute lung injury is the leading cause of transfusion-related morbidity and mortality. Clinical data on the pathogenesis of transfusion-related acute lung injury are sparse. The objective of the present study was to determine inflammation and coagulation pathways involved in the onset of transfusion-related acute lung injury. DESIGN Nested case-control study. S...

background: mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (ivig). anti-iga antibody has been proposed to be associated with development of such reactions.   objective: to assess the association between anti-iga levels of different isotypes and adverse reactions induced in immunodeficient pati...

BACKGROUND Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. METHODS Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of th...

Background and Objectives. Platelet concentrates (PC) obtained from Buffy-Coat (BC) may be diluted in a platelet additive solution (PAS). These PCs may reduce plasma-related adverse reactions. We have tried to assess the relationship between PAS PCs and adverse reactions. Materials and Methods. During 6 months, patients treated with intensive chemotherapy, participated in a prospective study an...

OBJECTIVE To analyze the profile of blood transfusion reactions in children and to identify the involved factors. METHODS This was a cross-sectional study in a tertiary pediatric teaching hospital from the public healthcare system, involving all children admitted from January to July of 2011 (5,437), of which 1,226 received blood transfusions, constituting the sample. A documental study was p...

In the past, anaemia in patients with established coronary artery disease, especially acute anaemia as a result of bleeding, has been treated with a relatively liberal use of allogenic red blood cell (RBC) transfusions. RBC transfusions are believed to increase oxygen delivery by increasing haemoglobin concentration. Therefore, transfusion would seem to be a logical approach, as anaemia is asso...