Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...

4. Newsome BB, Warnock DG, McClellan WM et al. Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Intern Med 2008; 168: 609–616 5. Coca SG, Yusuf B, Shlipak MG et al. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic rev...

BACKGROUND: COVID-19 has been at the forefront of public and scientific attention since initial report in December 2019. The kidney is one target organs the causative SARS-CoV-2 virus. OBJECTIVE: aim this article to discuss current understanding renal disease from a primary care perspective, with caveat that our knowledge pathogenesis, clinical course outcome still rapidly evolving. DISCUSSION:...

BACKGROUND Low values of estimated glomerular filtration rate (eGFR) predispose to acute kidney injury, and proteinuria is a marker of kidney disease. We aimed to investigate how eGFR and proteinuria jointly modified the risks of acute kidney injury and subsequent adverse clinical outcomes. METHODS We did a cohort study of 920,985 adults residing in Alberta, Canada, between 2002 and 2007. Par...

Kwon O, Hong S-M, Sutton TA, Temm CJ. Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury. Am J Physiol Renal Physiol 295: F351–F359, 2008. First published June 18, 2008; doi:10.1152/ajprenal.90276.2008.—Decreased renal blood flow following an ischemic insult contributes to a reduction in glomerul...

STUDY OBJECTIVE The study objective was to determine whether intravenous contrast administration for computed tomography (CT) is independently associated with increased risk for acute kidney injury and adverse clinical outcomes. METHODS This single-center retrospective cohort analysis was performed in a large, urban, academic emergency department with an average census of 62,179 visits per ye...

OBJECTIVE Identify prognostic factors related to mortality and non-recovery of renal function. METHODS A prospective single-center study was conducted at the intensive care medicine department of a university hospital between 2012 and 2015. Patients with acute kidney injury receiving continuous renal replacement therapy were included in the study. Clinical and analytical parameters were colle...

OBJECTIVE Ischemia/reperfusion (I/R) injury is a major cause of acute organ dysfunction and I/R related acute renal failure is a common clinical problem. Diabetes mellitus is defined as a risk factor for the development of acute renal injury as diabetic nephropathy compromises the renal tolerance to ischemia. The aim of this study was to investigate the protective effect of magnesium sulfate in...

Nephrotoxicity is a frequent complication of cisplatin-based chemotherapy, in which T cells are known to promote acute kidney injury. In this study, we examined the role of T cell immunoglobulin mucin 1 (Tim-1) in cisplatin-induced acute kidney injury using an inhibitory anti-Tim-1 antibody. Tim-1 acts to modulate T cell responses, but it is also expressed by damaged proximal tubules in the kid...