AIMS/HYPOTHESIS Fulminant type 1 diabetes (FT1D) is a distinct subtype of type 1 diabetes and is fatal without immediate diagnosis and treatment. At present, there are no biomarkers for early and predictive detection of FT1D. METHODS First, we analyzed a total of 6 serum samples from 3 patients with FT1D (1 sample in the acute and 1 in the sub-acute phases from each patient) by seromic analys...

OBJECTIVES Although cognitive behaviour therapy (CBT) and pharmacotherapy are equally effective in the acute treatment of adult depression, it is not known how they compare across the longer term. In this meta-analysis, we compared the effects of acute phase CBT without any subsequent treatment with the effects of pharmacotherapy that either were continued or discontinued across 6-18 months of ...

T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...

BACKGROUND The infectivity of the HIV-1 acute phase has been directly measured only once, from a retrospectively identified cohort of serodiscordant heterosexual couples in Rakai, Uganda. Analyses of this cohort underlie the widespread view that the acute phase is highly infectious, even more so than would be predicted from its elevated viral load, and that transmission occurring shortly after ...

purpose: to evaluate total plasma homocysteine level during the acute phase of central retinal vein occlusion (crvo) compared with a matched healthy group in iranian population, and determine whether hyperhomocysteinemia is also a risk factor for crvo. methods: a study group contains 54 patients presenting with crvo in recent one month, acute phase of the decease, was compared for fasting total...

doppler echocardiography (de) is known to be a valuable tool for detecting subclinical forms of valvular regurgitation (vrj in theacutephase of rheumatic fever (rf). previous studies have mostly dealt with the acute phase problem with only short-term follow-up. in this study, 24 children between 4-15 years of age (mean age ii.x±2.7 years) with rf without clinically diagnosed carditis (most with...

aim : to induce acute colitis progresses to chronicity in c57bl/6 mice by dextran sulfate sodium.   background : murine models are essential tools to understand ibd pathogenesis. among different types of chemically induced colitis models, the dextran sulfate sodium (dss)-induced colitis model is the most common model of ibd, due to its simplicity. patients and methods : male c57bl/6 mice 6–8 we...