acute paraplegia is a rare but catastrophic complication of surgeries performed on aorta and corrective operations of vertebral column. trauma to spinal cord after spinal anesthesia and ischemia of spinal cord also may lead to acute paraplegia. acute paraplegia as a complication of general anesthesia in surgeries performed on sites other than aorta and vertebral column is very rare. here we pre...

background: pediatric patients on chemotherapy are vulnerable to invasive fungal infection especially candida spices. resistance to antifungal agents has increased in candida spp., especially in non-albicans species. this study aims to assess the susceptibility of candida spp. strains isolated from children with acute leukemia less than 18 years. materials and methods: this prospective cross-se...

aim : the aim of this study is to determine the prevalence and genotype of human caliciviruses among children suffering from acute gastroenteritis referred to masih daneshvari hospital. background : human caliciviruses have been recognized as the major viral cause of acute gastroenteritis in all age groups worldwide. studies revealed that the noroviruses and sapoviruses could be divided into fi...

introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...

Progression through the cell cycle relies on oscillation of cyclin-dependent kinase (Cdk) activity. One mechanism for downregulating Cdk signaling is to activate opposing phosphatases. The Cdc14 family of phosphatases counteracts Cdk1 phosphorylation in diverse organisms to allow proper exit from mitosis and cytokinesis. However, the role of the vertebrate CDC14 phosphatases, CDC14A and CDC14B,...

SEASONAL cycles have long been analysed to study economic trends, but only within the past two decades has seasonal analysis been applied to congenital malformations. Since McKeown and Record (1951) carefully studied large numbers of anencephalic stillbirths and found a seasonal pattern of a winter excess and a summer trough, a steady output of articles dealing with the seasonality of malformat...

UNLABELLED Holoprosencephaly (HPE) is a congenital central nervous system malformation estimated to occur in 1/250 conceptuses and 1/10,000 live births. While the severe forms, which are incompatible with life, are easier to detect in the prenatal period, the milder forms can remain unrecognised. As this can have serious consequences for the pregnancy and malformation carriers it is of crucial ...

An experiment was undertaken to determine whether an overdose of the anthelmintic parbendazole could cause paralysis in lambs when given to ewes during the early stages of pregnancy. Out of a total of 68 lambs, born from ewes treated at various stages of gestation with parbendazole at 180 mg/kg, 5 showed the paralysis syndrome, 5 showed skeletal deformities, 2 were ataxic, while 1 foetus was ab...

The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain. Here, we show that classical mechanical concepts including deformations,...

The aim of this study was to evaluate the impact of folic acid use in pregnancy for the reduction of neural tube defects (NTDs) in the northwest region of Iran. We studied 243 women with pregnancies complicated by some forms of birth defect(s). These patients were identified by medical diagnostic tests as having a fetus with some types of congenital anomalies. The prevalence of NTDs among pregn...