نتایج جستجو برای: active bone formation

تعداد نتایج: 1210715  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Dwight A Towler

Cellular and molecular similarities between orthotopic versus heterotopic mineral deposition are beginning to emerge. During bone formation, the major orthotopic venue, two general mechanisms drive tissue mineralization1 (Table). With endochondral ossification, an avascular cartilaginous skeletal template is first established by chondrocytes; this cartilage template calcifies and is subsequentl...

Journal: :British medical journal 1982
K Farrington Z Varghese R A Baillod O N Fernando J F Moorhead

Out of 24 patients receiving haemodialysis who were subjected to parathyroidectomy, 13 developed hypophosphataemia; this persisted for 3-52 weeks (mean 10.6 weeks). Before operation these 13 patients had had significantly higher plasma alkaline phosphatase activities (p less than 0.01) and significantly higher values in iliac crest bone biopsy samples for active resorption surface and active fo...

Journal: :The New England journal of medicine 2014
Michael R McClung Andreas Grauer Steven Boonen Michael A Bolognese Jacques P Brown Adolfo Diez-Perez Bente L Langdahl Jean-Yves Reginster Jose R Zanchetta Scott M Wasserman Leonid Katz Judy Maddox Yu-Ching Yang Cesar Libanati Henry G Bone

BACKGROUND Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. METHODS In a phase 2, multicenter, international, randomized, placebo-controlled, parallel-group, eight-group study, we evaluated the efficacy and safety of romosozumab over a 12-month period in 419 postmenopausal women, 55 to 85...

2010
P. Narducci R. Bortul R. Bareggi V. Nicolin

Bone is continuously repaired and remodelled through well-coordinated activity of osteoblasts that form new bone and osteoclasts, which resorb it. Osteoblasts synthesize and secrete two key molecules that are important for osteoclast differentiation, namely the ligand for the receptor of activator of nuclear factor kappaB (RANKL) and its decoy receptor osteoprotegerin (OPG). Active membrane tra...

Journal: :Current osteoporosis reports 2011
Christopher S Kovacs

During embryonic and fetal development much of the skeleton initiates as a cartilaginous scaffold, which is progressively resorbed and replaced by bone. Endochondral bone formation continues until the growth plates fuse during puberty. At all life stages adequate delivery of mineral is required for the skeleton to achieve and maintain appropriate mineral content and strength. During fetal devel...

Journal: :Connective tissue research 2012
Jeong Joon Yoo Yoon-Jeong Park Sang-Hoon Rhee Heung Jae Chun Hee Joong Kim

There are growing demands for bioactive titanium implants that could shorten the healing period, promote faster rehabilitation, and thereby increase the success rate of treating patients with poor bone quality. A synthetic receptor-binding peptide mimicking bone morphogenetic protein-2 (BMP-2) was covalently linked to a titanium alloy with two types of topography--machined (TiMA) and rough (TiG...

Journal: :reports of biochemistry and molecular biology 0
amir peymani tel: +98 2813324971; fax: +98 281332497 maryam shahi cellular and molecular research center, qazvin university of medical sciences, qazvin, iran mehdi sahmani department of clinical biochemistry and medical genetics, cellular and molecular research center, qazvin university of medical sciences, qazvin, iran.

bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...

Journal: :Japanese journal of medicine 1987
T Okabe M Fujisawa J Watanabe F Takaku

To examine whether sarcoid epithelioid cells of granulomatous lesions produce colony-stimulating factor (CSF), a growth factor of monocyte-macrophage series, the primary culture of sarcoid epithelioid cells was carried out from 16 biopsied lymph nodes which contained sarcoid granulomas, CSF activity was demonstrated at high titer in the conditioned media from all the epithelioid cell cultures. ...

Journal: :Molecular and cellular endocrinology 2015
Jianbin Huang Lin Zhou Huafei Wu Nathan Pavlos Shek Man Chim Qian Liu Jinmin Zhao Wei Xue Ren Xiang Tan Jiming Ye Jun Xu Estabelle S Ang Haotian Feng Jennifer Tickner Jiake Xu Yue Ding

The RANKL-induced NF-κB signaling pathway is required for osteoclast formation and function. By screening for compounds that inhibit RANKL-induced NF-κB activation using a luciferase reporter gene assay in RAW264.7 cells, we identified triptolide (PG490), as a candidate compound targeting osteoclast differentiation and osteoclast-mediated osteolysis. Triptolide (PG490) is an active compound of ...

دانشپور, سید محمد مهدی , سجادی ساروی, مجید , شایسته آذر , مسعود, شفیعی, سید اسماعیل , محسنی بندپی, محمد علی , هادیان, عاطفه , کریمی نسب, محمد حسین ,

Abstract Background and purpose: Osteoarthritis (OA) is the most common cause of disability in the elderly and treatment is limited to primary care. Osteoarthritis knee disease is an active process of a diseaase involving knee cartilage and characterized by damaged cartilage, decreased joint space, sclerosis and thickening of bone under the cartilage, cysts and cartilage under the new bone f...

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