ytoplasmic structures are sites of active mammalian mRNA decay, according to Cougot et al. (page 31). The group had previously identified cytoplasmic foci that included two human mRNA decapping enzymes. They now add subunits of a deadenylase, exonuclease, and possible helicase to the list of proteins found at these sites. After inhibition of a 5 –3 exonuclease, poly(A) RNA accumulates at the sa...

Departments of Pediatrics and Obstetrics/Gynecology, National Taiwan University Hospital, Taipei, and Department of Pediatrics, Taiwan Provincial Kee-Lung Hospital, Keelung. Received: 15 August 2001. Revised: 11 December 2001. Accepted: 5 February 2002. Reprint requests and correspondence to: Dr. Mei-Hwan Wu, Department of Pediatrics, National Taiwan University Hospital, 7 Chung-Shan South Road...

We have used immunofluorescent localization to examine the distribution of MLH1 (MutL homolog) foci on synaptonemal complexes (SCs) from juvenile male mice. MLH1 is a mismatch repair protein necessary for meiotic recombination in mice, and MLH1 foci have been proposed to mark crossover sites. We present evidence that the number and distribution of MLH1 foci on SCs closely correspond to the numb...

Single-span ropeways based on autonomous self-propelled wheeled chassis of high load capacity and cross-country capability are a promising type mobile transport overloading equipment for the rapid creation logistics infrastructure sustainable development hard-to-reach areas with complex natural terrain. They can also be effectively used deployment during operations in foci or man-made disasters...

Much everyday behavior is implicitly guided by hypotheses about the world which are monitored and updated in the light of changing circumstances. The process of translating these hypotheses into behavior typically involves implementing choices, often based on incompletely specified information. The present study aimed at modeling these processes to determine the neural substrates of hypothesis ...

BRCA1, which is mutated in the familial forms of breast and ovarian cancer, plays important roles in genome stability through its participation in DNA damage response (DDR) following double-stranded breaks (DsBs). BRCA1 activates the checkpoint pathway to retard cell cycle progression and stimulates repair of the DsBs (reviewed in ref. 1). it is recruited to the damaged chromatin through an int...

Epstein-Barr virus (EBV) is an oncogenic herpesvirus that is ubiquitous in the human population. Early after EBV infection in vitro, primary human B cells undergo a transient period of hyper-proliferation, which results in replicative stress and DNA damage, activation of the DNA damage response (DDR) pathway and, ultimately, senescence. In this study, we investigated DDR-mediated senescence in ...

The neural correlates of developmental dyslexia have been investigated intensively over the last two decades and reliable evidence for a dysfunction of left-hemispheric reading systems in dyslexic readers has been found in functional neuroimaging studies. In addition, structural imaging studies using voxel-based morphometry (VBM) demonstrated grey matter reductions in dyslexics in several brain...